Seydanur Dengizek Eltas, Serkan Dundar, Abubekir Eltas, Aysun Bay Karabulut, Onder Otlu, Arife Cicek
Canakkale Onsekiz Mart University, Faculty of Dentistry, Department of Periodontology, Canakkale, Turkey.
Firat University, Faculty of Dentistry, Department of Periodontology, Elazıg, Turkey.
J Appl Oral Sci. 2019 Jan 14;27:e20180108. doi: 10.1590/1678-7757-2018-0108.
This study aims to evaluate the clinical and biochemical (oxidative stress and pro-inflammatory mediators) effects of the gaseous ozone use accompanied by scaling and root planning (SRP) in periodontal treatment.
The study population consisted of 40 patients with chronic periodontitis (CP) randomly sorted into two groups of 20. The experimental group received SRP plus 3 watts gaseous ozone in two separate applications five days apart, whereas the control group received SRP plus placebo. Clinical periodontal parameters were assayed and saliva samples were taken before the initial and one month after the second treatment. Periodontal examination assessed plaque index (PI), gingival index (GI), probing depth, and clinical attachment level (CAL). Total antioxidant status (TAS), total oxidant status (TOS), nitric oxide (NO), 8-hydroxy-2'-deoxyguanosine (8-OHdG), myeloperoxidase (MPO), glutathione (GSH), malondialdehyde (MDA), and transforming growth factor-beta (TGF-β) levels were evaluated from saliva samples.
Changes following treatment in PI, GI, probing depth, and CAL scores were similar for both groups (p>0.05). Of note, TGF-β levels were observed to be higher in the treatment group than in controls (p<0.05). Changes in 8-OHdG, TAS, TOS, NO, MPO, GSH and MDA levels, however, were not significantly different between groups (p>0.05).
The findings of this study indicate that SRP plus gaseous ozone versus SRP alone does not correlate to a significant improvement in periodontal recovery.
本研究旨在评估在牙周治疗中，气态臭氧联合龈下刮治及根面平整术（SRP）的临床和生化（氧化应激及促炎介质）效果。
研究对象为40例慢性牙周炎（CP）患者，随机分为两组，每组20例。实验组接受SRP联合3瓦气态臭氧治疗，分两次单独应用，间隔5天；对照组接受SRP联合安慰剂治疗。在初次治疗前及第二次治疗后1个月测定临床牙周参数并采集唾液样本。牙周检查评估菌斑指数（PI）、牙龈指数（GI）、探诊深度及临床附着水平（CAL）。从唾液样本中评估总抗氧化状态（TAS）、总氧化状态（TOS）、一氧化氮（NO）、8-羟基-2'-脱氧鸟苷（8-OHdG）、髓过氧化物酶（MPO）、谷胱甘肽（GSH）、丙二醛（MDA）及转化生长因子-β（TGF-β）水平。
两组治疗后PI、GI、探诊深度及CAL评分的变化相似（p>0.05）。值得注意的是，观察到治疗组的TGF-β水平高于对照组（p<0.05）。然而，两组间8-OHdG、TAS、TOS、NO、MPO、GSH及MDA水平的变化无显著差异（p>0.05）。
本研究结果表明，SRP联合气态臭氧与单独使用SRP相比，在牙周恢复方面并无显著改善。
