Faculty of Dentistry, Department of Periodontology, Erciyes University, Kayseri, Turkey.
Faculty of Dentistry, Department of Periodontology, Bezm-i Alem Vakif University, Istanbul, Turkey.
Oral Dis. 2019 May;25(4):1195-1202. doi: 10.1111/odi.13060. Epub 2019 Mar 3.
The aim of this randomized split-mouth clinical trial was to evaluate the effects of ozone therapy on clinical and biochemical parameters of moderate to severe generalized periodontitis patients after non-surgical periodontal therapy.
A total of 36 moderate to severe generalized periodontitis patients were included in the study. The patients were systemically healthy and 18 to 64 years of age. Periodontal parameters, including plaque index (PI), gingival index (GI), probing depth (PD), percentage of bleeding on probing, percentage of pockets deeper than 5 mm and clinical attachment level (CAL), and percentage of ≥3 mm CAL, were evaluated at baseline and 3 months following periodontal therapy. All participants were treated non-surgically. Topical gaseous ozone was applied into periodontal pockets twice a week for 2 weeks during active periodontal therapy. Gingival crevicular fluid pentraxin-3 (PTX-3), interleukin-1β (IL-1β), and high sensitivity C-reactive protein (Hs-CRP) were evaluated. All statistical data were analyzed using SPSS software.
Total of 36 participants completed the study (18 males, 18 females). PI, GI, PD, percentage of bleeding on probing, percentage of pockets deeper than 5 mm and CAL, and percentage of ≥3 mm CAL were improved, and there were no significant differences between the two sides. All inflammatory parameters, PTX-3, Hs-CRP, and IL-1, were reduced at 3-month follow-up. Only the decrease in PTX-3 levels between baseline and 3-month follow-up was statistically significant.
Ozone therapy did not have any additional effect on periodontal parameters. All cytokines were reduced after periodontal therapy. Only PTX-3 levels were significantly lower at ozone sites compared to those at the control sites.
本随机分组对照临床试验旨在评估臭氧疗法对非手术牙周治疗后中重度广泛性牙周炎患者的临床和生化参数的影响。
共纳入 36 例中重度广泛性牙周炎患者。患者全身健康，年龄 18-64 岁。在牙周治疗前和治疗后 3 个月评估牙周参数，包括菌斑指数（PI）、牙龈指数（GI）、探诊深度（PD）、探诊出血百分比、探诊深度超过 5mm 的百分比、临床附着丧失（CAL）和大于 3mm 的 CAL 百分比。所有患者均接受非手术治疗。在积极的牙周治疗期间，每周两次将局部气态臭氧应用于牙周袋内，共 2 周。评估龈沟液 pentraxin-3（PTX-3）、白细胞介素-1β（IL-1β）和高敏 C 反应蛋白（Hs-CRP）。所有统计数据均使用 SPSS 软件进行分析。
共有 36 名参与者完成了研究（男性 18 名，女性 18 名）。PI、GI、PD、探诊出血百分比、探诊深度超过 5mm 的百分比、CAL 和大于 3mm 的 CAL 百分比均得到改善，且两侧之间无显著差异。所有炎症参数，PTX-3、Hs-CRP 和 IL-1β，在 3 个月随访时均降低。仅在基线和 3 个月随访时 PTX-3 水平的下降具有统计学意义。
臭氧治疗对牙周参数没有任何额外作用。牙周治疗后所有细胞因子均降低。仅在臭氧治疗部位的 PTX-3 水平明显低于对照部位。
