慢性乙型肝炎病毒感染患者肝内cccDNA与肝脏炎症严重程度之间的关联。
Association between intrahepatic cccDNA and the severity of liver inflammation in chronic hepatitis B virus infection patients.
作者信息
Zhao Suxian, Dong Chen, Chang Chudi, Zhang Jiaming, Li Jing, Zhang Xiaoxiao, Ren Weiguang, Zhang Ying, Nan Yuemin
机构信息
Department of Traditional and Western Medical Hepatology, Hebei Medical University Third Hospital, the Key Laboratory of Hepatic Fibrosis Mechanisms of Chronic Liver Diseases in Hebei Province, Hebei International Science and Technology Cooperation Base - Hebei International Joint Research Center for Molecular Diagnosis of Liver Cancer, Shijiazhuang, China.
出版信息
Front Med (Lausanne). 2025 Jan 24;11:1519686. doi: 10.3389/fmed.2024.1519686. eCollection 2024.
BACKGROUND AND AIMS
This research aimed to examine the association between hepatitis B virus (HBV) covalently closed circular DNA (cccDNA) and liver inflammation in chronic hepatitis B (CHB) infection patients.
METHODS
From August 2013 to June 2022, CHB patients at Hebei Medical University Third Hospital (Hebei, China) were recruited. Intrahepatic cccDNA was quantified and its association with liver inflammation was analyzed. Liver inflammation was assessed using the Ishak-modified histological activity index (HAI). Biochemical and viral indicators as well as hepatic inflammation biomarkers were monitored.
RESULTS
In total, 55 CHB patients were enrolled. The average HBV-cccDNA level was markedly elevated in HBeAg+ patients compared to HBeAg patients. Intrahepatic cccDNA levels differed significantly in different liver inflammation groups and showed a positive correlation with the HAI score for hepatic inflammation.
CONCLUSION
HBV-cccDNA level was associated with liver inflammation.
背景与目的
本研究旨在探讨慢性乙型肝炎（CHB）感染患者中乙型肝炎病毒（HBV）共价闭合环状DNA（cccDNA）与肝脏炎症之间的关联。
方法
2013年8月至2022年6月，招募了河北医科大学第三医院（中国河北）的CHB患者。对肝内cccDNA进行定量，并分析其与肝脏炎症的关联。使用Ishak改良组织学活动指数（HAI）评估肝脏炎症。监测生化和病毒指标以及肝脏炎症生物标志物。
结果
共纳入55例CHB患者。与HBeAg阴性患者相比，HBeAg阳性患者的平均HBV-cccDNA水平显著升高。不同肝脏炎症组的肝内cccDNA水平存在显著差异，且与肝脏炎症的HAI评分呈正相关。
结论
HBV-cccDNA水平与肝脏炎症相关。
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