Hollingsworth T J, Meshkat Bahar, Wang Xiangdi, White William A, Marquez-Wilkins Esther, Jablonski Monica M
Department of Ophthalmology, University of Tennessee Health Science Center, Memphis, TN, USA.
Department of Anatomy and Neurobiology, University of Tennessee Health Science Center, Memphis, TN, USA.
Adv Exp Med Biol. 2025;1468:45-50. doi: 10.1007/978-3-031-76550-6_8.
The study of retinal degenerations (RDs) is a field involving all aspects of retinal anatomy, physiology, and genetics. RDs are heterogeneous involving many genes and systems underlying their pathogeneses. To understand these processes, animal models act as surrogates for human studies; however, an ever-existent issue is few models offer high-fidelity and direct correlations to the human condition. Our recent work has established an animal model that is able to fill both needs. The BXD32 mouse exhibits a polygenic inherited retinal dystrophy (IRD) that correlates to human disease through aberrant disc formation and chronic retinal inflammation working in concert with the genetic underliers to advance the disease. This model can serve to test anti-inflammatory treatments directly to affected tissue avoiding systemic issues as well as understanding the pathophysiology of human IRDs.
视网膜变性（RDs）的研究是一个涉及视网膜解剖学、生理学和遗传学各个方面的领域。RDs具有异质性，其发病机制涉及许多基因和系统。为了理解这些过程，动物模型充当人类研究的替代物；然而，一个一直存在的问题是，很少有模型能与人类疾病有高度保真度和直接的相关性。我们最近的工作建立了一种能够满足这两个需求的动物模型。BXD32小鼠表现出一种多基因遗传性视网膜营养不良（IRD），它通过异常的视盘形成和慢性视网膜炎症与遗传因素协同作用导致疾病，从而与人类疾病相关。该模型可用于直接对受影响组织进行抗炎治疗测试，避免全身问题，同时有助于理解人类IRD的病理生理学。
