小胶质细胞在青光眼病理中的作用。
Role of Microglia in Glaucomatous Pathology.
作者信息
Somerville McKenna M, Garner Mary Anne, Girkin Christopher A, Gross Alecia K
机构信息
Departments of Neurobiology, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
Departments of Ophthalmology and Visual Sciences, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
出版信息
Adv Exp Med Biol. 2025;1468:149-153. doi: 10.1007/978-3-031-76550-6_25.
Glaucoma is a leading cause of irreversible blindness worldwide and is characterized by progressive loss of retinal ganglion cells. Much research has gone into further understanding the pathology of this disease, including the extent to which microglia modulate its pathogenesis. This has revealed a role of the innate immune system in glaucomatous pathology that begins before the onset of retinal ganglion cell dysfunction and degeneration. Stimulation of the innate immune response triggers downstream cascades implicated in chronic disease, making immune pathways invaluable in our understanding of glaucomatous pathology. This review will focus on evidence that supports the role of the microglial immunologic response in the pathogenesis of glaucoma.
青光眼是全球不可逆性失明的主要原因，其特征是视网膜神经节细胞逐渐丧失。为了进一步了解这种疾病的病理，人们进行了大量研究，包括小胶质细胞对其发病机制的调节程度。这揭示了先天免疫系统在青光眼病理过程中的作用，该作用在视网膜神经节细胞功能障碍和退化之前就已开始。先天免疫反应的刺激会触发与慢性疾病相关的下游级联反应，这使得免疫途径在我们对青光眼病理的理解中具有重要价值。本综述将聚焦于支持小胶质细胞免疫反应在青光眼发病机制中作用的证据。
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