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病例报告:非典型新冠后科根综合征

Case Report: Atypical post-COVID Cogan's syndrome.

作者信息

Mezri Sameh, Zitouni Chaima, Sleimi Wafa, Bouzidi Mayssa, Sameh Sayhi

机构信息

University of Tunis El-Manar, Tunis, Tunisia.

ENT Department, Military Hospital of Tunis, Montfleury, Tunis, 1008, Tunisia.

出版信息

F1000Res. 2024 Dec 20;13:1104. doi: 10.12688/f1000research.155250.1. eCollection 2024.

Abstract

BACKGROUND

Cogan's syndrome is a rare autoimmune disorder characterized by ocular inflammation, vestibulocochlear dysfunction, and systemic vasculitis.

CASE PRESENTATION

We report a 28-year-old female who experienced decreased visual acuity and ocular redness one month after a COVID-19 infection, with ophthalmological signs linked to keratitis, uveitis and retinal vasculitis. Two weeks later, she developed vertigo, tinnitus, and sudden hearing loss, leading to a diagnosis of Cogan's disease. The patient received corticosteroid therapy, resulting in regression of ophthalmological signs, but progressed to complete deafness. One month later, she presented with lymphocytic meningitis and high intracranial pressure, which improved under treatment. The patient later received cochlear implants.

OBJECTIVE

This case report aims to highlight an atypical presentation of Cogan's syndrome with neurological involvement following a COVID-19 infection. This case contributes to the limited literature on such presentations.

CONCLUSION

Our case is one of only two reported instances of Cogan's syndrome presenting with neurological signs post-COVID-19 infection, underscoring the rarity and complexity of this condition.

摘要

背景

科根综合征是一种罕见的自身免疫性疾病,其特征为眼部炎症、前庭蜗功能障碍和系统性血管炎。

病例介绍

我们报告一名28岁女性,在感染新型冠状病毒肺炎1个月后出现视力下降和眼红,伴有与角膜炎、葡萄膜炎和视网膜血管炎相关的眼科体征。两周后,她出现眩晕、耳鸣和突发性听力损失,从而诊断为科根病。患者接受了皮质类固醇治疗,眼科体征消退,但进展为完全性耳聋。1个月后,她出现淋巴细胞性脑膜炎和高颅内压,经治疗后病情好转。该患者后来接受了人工耳蜗植入。

目的

本病例报告旨在强调新型冠状病毒肺炎感染后出现神经系统受累的科根综合征的非典型表现。本病例丰富了关于此类表现的有限文献。

结论

我们的病例是仅有的两例报告的新型冠状病毒肺炎感染后出现神经系统体征的科根综合征病例之一,凸显了这种疾病的罕见性和复杂性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c29/11812987/b46315b7ec88/f1000research-13-175760-g0000.jpg

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