van Houten M, Posner B I
Nature. 1979 Dec 6;282(5739):623-5. doi: 10.1038/282623a0.
The brain has generally been considered an insulin-independent organ, because insulin does not apparently exert a direct effect on brain glucose consumption. Recently, however, insulin receptors have been detected throughout the central nervous system (CNS) of several species. Since important insights into the functional significance of brain insulin receptors might be provided by identification of the cell type(s) possessing these receptors, we have attempted to localise them morphologically using light and electron microscope autoradiography. We report here results indicating that blood vessels throughout the CNS of the rat bind plasma insulin rapidly and with considerable specificity.
大脑通常被认为是一个不依赖胰岛素的器官，因为胰岛素显然不会对大脑的葡萄糖消耗产生直接影响。然而，最近在几个物种的整个中枢神经系统（CNS）中都检测到了胰岛素受体。由于确定拥有这些受体的细胞类型可能会为深入了解大脑胰岛素受体的功能意义提供重要线索，我们试图通过光学显微镜和电子显微镜放射自显影技术从形态学上对它们进行定位。我们在此报告的结果表明，大鼠整个中枢神经系统中的血管能快速且高度特异性地结合血浆胰岛素。
