东莨菪碱和甲基东莨菪碱联合使用对毒扁豆碱诱导的致死性的拮抗作用。

Antagonism of physostigmine induced lethality by a combination of scopolamine and methscopolamine.

作者信息

Janowsky D S, Berkowitz A, Turken A, Risch S C

出版信息

Acta Pharmacol Toxicol (Copenh). 1985 Feb;56(2):154-7. doi: 10.1111/j.1600-0773.1985.tb01269.x.

DOI:10.1111/j.1600-0773.1985.tb01269.x

Abstract

The antagonistic effects of scopolamine, methscopolamine, and a combination of methscopolamine and scopolamine were evaluated in preventing physostigmine induced lethality in Swiss Webster mice. Low dose scopolamine was found to be highly effective in reversing high dose (3 X the LD100) physostigmine induced lethality, in contrast to methscopolamine, which was ineffective except in very high doses. A combination of scopolamine and methscopolamine was more effective than either drug alone.

摘要

在瑞士韦伯斯特小鼠中，评估了东莨菪碱、甲基东莨菪碱以及甲基东莨菪碱与东莨菪碱联合用药在预防毒扁豆碱诱导的致死作用方面的拮抗效果。结果发现，低剂量东莨菪碱在逆转高剂量（3倍LD100）毒扁豆碱诱导的致死作用方面非常有效，与之形成对比的是，甲基东莨菪碱除了在非常高的剂量下外均无效。东莨菪碱与甲基东莨菪碱联合用药比单独使用任何一种药物都更有效。