Wang Jiong, Du Jiqing, Wang Minxiu, Jin Mengyun, Tang Zhihua, Mao Yuqin
Department of Pharmacy, Shaoxing People's Hospital, Shaoxing, China.
School of Life and Health Technology, Dongguan University of Technology, Dongguan, China.
Front Nutr. 2025 Jan 28;12:1509232. doi: 10.3389/fnut.2025.1509232. eCollection 2025.
Non-alcoholic fatty liver disease (NAFLD) is a significant health burden in youths and young adults, and the trend toward younger onset of NAFLD is alarming. Utilizing data from the Global Burden of Disease (GBD) 2021 study, this study assessed the burden and trends of NAFLD in youths and young adults aged 15-39 from 1990 to 2021 and extracted data from this study on the incidence, prevalence, death, and disability-adjusted life-years (DALYs) rates of NAFLD. We evaluated the global temporal trend of NAFLD from 1990 to 2021 with estimated annual percentage change (EAPC) and age-standardized rate (ASR). The Bayesian age-period-cohort (BAPC) model was used to predict future trends of the NAFLD burden to 2035. We found that the global burden of NAFLD in youths and young adults has risen steadily from 1990 to 2021, and projects to increase to 2035, which places enormous pressure on society. To alleviate this burden, implementing measures targeting risk factors such as glycemic control and smoking cessation is necessary.
非酒精性脂肪性肝病（NAFLD）是青少年和青年人群的一项重大健康负担，且NAFLD发病年龄趋于年轻化的趋势令人担忧。本研究利用全球疾病负担（GBD）2021研究的数据，评估了1990年至2021年15至39岁青少年和青年人群中NAFLD的负担及趋势，并从该研究中提取了NAFLD的发病率、患病率、死亡率和伤残调整生命年（DALY）率的数据。我们用估计年百分比变化（EAPC）和年龄标准化率（ASR）评估了1990年至2021年NAFLD的全球时间趋势。采用贝叶斯年龄-时期-队列（BAPC）模型预测到2035年NAFLD负担的未来趋势。我们发现，1990年至2021年，青少年和青年人群中NAFLD的全球负担稳步上升，并预计到2035年还会增加，这给社会带来了巨大压力。为减轻这一负担，有必要实施针对血糖控制和戒烟等危险因素的措施。
