Fusco Giovanna, Paradiso Rubina, Cardillo Lorena, Salvia Maria Antonia, Dodaro Saveria, Del Monaco Veronica, Scarpelli Gianfranco, Greco Francesca, Rinaldi Antonio, Barca Lorella, Ambrogio Stefania, Limone Antonio, De Carlo Esterina, Borriello Giorgia
Department of Animal Health, Istituto Zooprofilattico Sperimentale del Mezzogiorno, Naples, Italy.
Departmental Unit of Genetics, Bioinformatics, and Biobank, Istituto Zooprofilattico Sperimentale del Mezzogiorno, Naples, Italy.
Front Microbiol. 2025 Jan 28;16:1519247. doi: 10.3389/fmicb.2025.1519247. eCollection 2025.
Neonatal meningitis and sepsis were diagnosed in a 32-day-old preterm-born infant. was isolated from cerebrospinal fluid and blood. Next-generation sequencing revealed that the strain was serotype 2 sequence type 1, and contained the and genes, which are responsible for resistance to macrolides and tetracycline, along with several pilus-associated genes and 20 virulence factors. High homology was observed with previously identified human and swine strains in the same area. meningitis and sepsis are mainly reported in adults, related to direct contact with pigs or contaminated pork meat consumption, while it is rarely reported in children. Herein, we describe the first case of in a newborn associated with meningitis and antimicrobial resistance. The rates of resistance to tetracyclines, lincosamides, and macrolides for this bacterium are increasing and are creating concern worldwide. Altogether, our findings highlight the importance of investigating in cases of neonatal meningitis, as well as the necessity of assessing the antimicrobial profile to obtain useful information for developing targeted therapies.
一名32天大的早产儿被诊断出患有新生儿脑膜炎和败血症。从脑脊液和血液中分离出了[细菌名称未给出]。下一代测序显示，该菌株为血清型2序列型1，含有负责对大环内酯类和四环素耐药的[基因名称未给出]和[基因名称未给出]基因，以及几个菌毛相关基因和20个毒力因子。在同一地区，与先前鉴定的人源和猪源菌株具有高度同源性。[细菌名称未给出]脑膜炎和败血症主要在成人中报道，与直接接触猪或食用受污染的猪肉有关，而在儿童中很少报道。在此，我们描述了首例与脑膜炎和抗菌药物耐药性相关的新生儿[细菌名称未给出]感染病例。这种细菌对四环素、林可酰胺类和大环内酯类的耐药率正在上升，引起了全球关注。总之，我们的研究结果突出了在新生儿脑膜炎病例中调查[细菌名称未给出]的重要性，以及评估抗菌谱以获取有用信息用于制定靶向治疗的必要性。
