Institute for Glycomics, Griffith University, Gold Coast, QLD, Australia.
Queensland Alliance for Agriculture and Food Innovation, The University of Queensland, St. Lucia, QLD, Australia.
Adv Microb Physiol. 2021;78:217-257. doi: 10.1016/bs.ampbs.2020.12.002. Epub 2021 Jan 22.
Streptococcus suis is a major cause of respiratory tract and invasive infections in pigs and is responsible for a substantial disease burden in the pig industry. S. suis is also a significant cause of bacterial meningitis in humans, particularly in South East Asia. S. suis expresses a wide array of virulence factors, and although many are described as being required for disease, no single factor has been demonstrated to be absolutely required. The lack of uniform distribution of known virulence factors among individual strains and lack of evidence that any particular virulence factor is essential for disease makes the development of vaccines and treatments challenging. Here we review the current understanding of S. suis virulence factors and their role in the pathogenesis of this important zoonotic pathogen.
猪链球菌是猪呼吸道和侵袭性感染的主要病原体，也是猪养殖业中重大疾病负担的罪魁祸首。猪链球菌也是人类细菌性脑膜炎的重要病因，尤其在东南亚地区。猪链球菌表达多种毒力因子，尽管许多因子被描述为疾病所必需，但尚无单一因子被证明是绝对必需的。在不同菌株中，已知毒力因子的分布并不均匀，也没有证据表明任何特定的毒力因子对疾病是必不可少的，这使得疫苗和治疗方法的开发具有挑战性。本文综述了猪链球菌毒力因子的最新研究进展，及其在这种重要人畜共患病病原体发病机制中的作用。
