Narducci F, Bassotti G, Gaburri M, Farroni F, Morelli A
Am J Gastroenterol. 1985 May;80(5):317-9.
Patients with the irritable colon syndrome have an exaggerated and/or prolonged colonic motor response to eating. This is believed to be the cause of their postprandial complaints. Since the flux of calcium ions across cell membranes plays a major role in the contractions of the gastrointestinal smooth muscle, we investigated the effect of nifedipine, a calcium channel blocker, on the gastrocolonic response in nine patients with the irritable colon syndrome. Colonic myoelectric and contractile activity was recorded during fasting and after a 1000-cal mixed meal, either with or without nifedipine (20 mg sublingually) administration. Nifedipine reduced the postprandial increase of both spike potential activity and motility index. This effect of acute administration of the drug provides rational support to test nifedipine in clinical trials as a possible means for treating the irritable colon syndrome.
肠易激综合征患者对进食有过度和/或延长的结肠运动反应。这被认为是他们餐后不适的原因。由于钙离子跨细胞膜的流动在胃肠道平滑肌收缩中起主要作用，我们研究了钙通道阻滞剂硝苯地平对9例肠易激综合征患者胃结肠反应的影响。在禁食期间以及进食1000卡路里混合餐后，记录结肠肌电和收缩活动，记录时分别给予或不给予硝苯地平（20mg舌下含服）。硝苯地平降低了餐后峰电位活动和运动指数的增加。该药急性给药的这种作用为在临床试验中测试硝苯地平作为治疗肠易激综合征的一种可能手段提供了合理依据。
