系统神经免疫学：当前瓶颈、研究重点及未来方向
Systems neuroimmunology: current bottlenecks, research priorities and future directions.
作者信息
Iyer Harini, Benoist Christophe, Bilbo Staci D, Boulanger Lisa M, Burton Michael D, Daniels Brian P, Deczkowska Aleksandra, Flajnik Martin F, Gareau Mélanie G, Grace Peter M, Irazoqui Javier E, Rosi Susanna, Salinas Irene, Schaefer Anne, Sokol Caroline L, Williams Dionna W, Klein Robyn S
机构信息
Department of Biosciences, Rice University, Houston, TX, USA.
Department of Immunology, Harvard Medical School, Boston, MA, USA.
出版信息
Nat Immunol. 2025 Mar;26(3):325-329. doi: 10.1038/s41590-025-02092-z.
Abstract
Strategies to advance the field of neuroimmunology by embracing its complexity via inclusion of its multidisciplinary properties were discussed at a meeting in Cold Spring Harbor. Attendees proposed fostering of open communications and funding of collaborations across disciplines, and the recognition that our understanding of the neuroimmune system requires interdisciplinary science.
摘要
在冷泉港的一次会议上，讨论了通过纳入神经免疫学的多学科特性来拥抱其复杂性，从而推动该领域发展的策略。与会者提议促进跨学科的开放交流与合作资金投入，并认识到我们对神经免疫系统的理解需要跨学科科学。
相似文献
1
Systems neuroimmunology: current bottlenecks, research priorities and future directions.系统神经免疫学：当前瓶颈、研究重点及未来方向
Nat Immunol. 2025 Mar;26(3):325-329. doi: 10.1038/s41590-025-02092-z.
2
Frontiers and future perspectives of neuroimmunology.神经免疫学的前沿与未来展望
Fundam Res. 2022 Oct 19;4(2):206-217. doi: 10.1016/j.fmre.2022.10.002. eCollection 2024 Mar.
3
Research priorities for neuroimmunology: identifying the key research questions to be addressed by 2030.神经免疫学的研究重点：确定到2030年需要解决的关键研究问题。
Wellcome Open Res. 2021 Jul 29;6:194. doi: 10.12688/wellcomeopenres.16997.1. eCollection 2021.
4
Outcomes and future directions for neuroimmunology/multiple sclerosis fellowship training: Survey of recent trainees.神经免疫/多发性硬化症研究员培训的结果和未来方向：对最近的受训者进行调查。
Mult Scler Relat Disord. 2020 Sep;44:102296. doi: 10.1016/j.msard.2020.102296. Epub 2020 Jun 10.
5
Surface-enhanced Raman spectroscopy: bottlenecks and future directions.表面增强拉曼光谱：瓶颈与未来方向。
Chem Commun (Camb). 2017 Dec 19;54(1):10-25. doi: 10.1039/c7cc05979e.
6
A Comprehensive Review on Neuroimmunology: Insights from Multiple Sclerosis to Future Therapeutic Developments.神经免疫学综述：从多发性硬化症到未来治疗进展的见解
Biomedicines. 2023 Sep 8;11(9):2489. doi: 10.3390/biomedicines11092489.
7
An embedded implementation research initiative to tackle service delivery bottlenecks in the expanded programme on immunisation in Pakistan: Overview and reflections.在巴基斯坦扩大免疫规划中解决服务提供瓶颈问题的嵌入式实施研究倡议：概述与反思。
J Glob Health. 2021 May 8;11:06003. doi: 10.7189/jogh.11.06003.
8
The state of macro-energy systems research: Common critiques, current progress, and research priorities.宏观能源系统研究现状：常见批评、当前进展及研究重点。
iScience. 2023 Mar 5;26(4):106325. doi: 10.1016/j.isci.2023.106325. eCollection 2023 Apr 21.
9
Research priorities for economic analyses of prevention: current issues and future directions.预防措施经济分析的研究重点：当前问题与未来方向
Prev Sci. 2014 Dec;15(6):789-98. doi: 10.1007/s11121-013-0429-z.
10
Systems neuroimmunology: a review of multiomics methodologies to characterize neuroimmunological interactions in spinal and cranial diseases.系统神经免疫学期刊：多组学方法综述，用于描述脊髓和颅部疾病中的神经免疫相互作用。
Neurosurg Focus. 2022 Feb;52(2):E9. doi: 10.3171/2021.11.FOCUS21571.
引用本文的文献
1
Neurological Complications in Inborn Errors of Immunity: A Scoping Review of Clinical Spectrum, Pathophysiological Mechanisms, and Therapeutic Strategies.免疫缺陷病的神经系统并发症：临床谱、病理生理机制及治疗策略的范围综述
Clin Rev Allergy Immunol. 2025 Jul 18;68(1):67. doi: 10.1007/s12016-025-09078-7.
2
Neuro-immune crosstalk: focus on innate lymphoid cells.神经-免疫相互作用：聚焦于固有淋巴细胞
Trends Immunol. 2025 Jul 11. doi: 10.1016/j.it.2025.06.005.
本文引用的文献
1
Universal recording of immune cell interactions in vivo.在体实时记录免疫细胞相互作用。
Nature. 2024 Mar;627(8003):399-406. doi: 10.1038/s41586-024-07134-4. Epub 2024 Mar 6.
2
Sex and gender differences in pain.疼痛的性别差异。
Int Rev Neurobiol. 2022;164:277-307. doi: 10.1016/bs.irn.2022.06.013. Epub 2022 Jul 30.
3
Clickable Biomaterials for Modulating Neuroinflammation.可点击生物材料在神经炎症调节中的应用。
Int J Mol Sci. 2022 Jul 31;23(15):8496. doi: 10.3390/ijms23158496.
4
Barcoded viral tracing of single-cell interactions in central nervous system inflammation.对中枢神经系统炎症中单细胞相互作用的条码病毒追踪。
Science. 2021 Apr 23;372(6540). doi: 10.1126/science.abf1230.
5
T Cells Plead for Rejuvenation and Amplification; With the Brain's Neurotransmitters and Neuropeptides We Can Make It Happen.T 细胞呼吁更新和扩增；有了大脑的神经递质和神经肽，我们就能做到这一点。
Front Immunol. 2021 Mar 22;12:617658. doi: 10.3389/fimmu.2021.617658. eCollection 2021.
6
Advances in microfluidic in vitro systems for neurological disease modeling.微流控体外系统在神经疾病建模方面的进展。
J Neurosci Res. 2021 May;99(5):1276-1307. doi: 10.1002/jnr.24794. Epub 2021 Feb 13.
7
Physiological blood-brain transport is impaired with age by a shift in transcytosis.随着年龄增长，经细胞转运的改变会损害生理性血脑转运。
Nature. 2020 Jul;583(7816):425-430. doi: 10.1038/s41586-020-2453-z. Epub 2020 Jul 1.
8
Microglia and sexual differentiation of the developing brain: A focus on ontogeny and intrinsic factors.小胶质细胞和发育中大脑的性别分化：关注个体发生和内在因素。
Glia. 2020 Jun;68(6):1085-1099. doi: 10.1002/glia.23753. Epub 2019 Nov 19.
9
Corticosteroid signaling at the brain-immune interface impedes coping with severe psychological stress.皮质类固醇信号在大脑-免疫界面阻碍了应对严重心理压力的能力。
Sci Adv. 2019 May 29;5(5):eaav4111. doi: 10.1126/sciadv.aav4111. eCollection 2019 May.
10
Neuroscience Needs Behavior: Correcting a Reductionist Bias.神经科学需要行为学：纠正简化论偏见。
Neuron. 2017 Feb 8;93(3):480-490. doi: 10.1016/j.neuron.2016.12.041.
Zotero 插件