Reiriz Manuel, Beltrán-Velasco Ana Isabel, Echeverry-Alzate Víctor, Martínez-Miguel Esther, Gómez-Senent Silvia, Uceda Sara, Clemente-Suárez Vicente Javier
NBC Group, School of Life and Nature Sciences, Nebrija University, 28248 Madrid, Spain.
Faculty of Sports Sciences, Universidad Europea de Madrid, Tajo Street, s/n, 28670 Madrid, Spain.
Nutrients. 2025 Jan 22;17(3):391. doi: 10.3390/nu17030391.
: This systematic review focused on collecting the most significant findings on the impact of the administration of (or subps. infantis) and , alone, in conjunction, or in combination with other strains, in the treatment of neurodegenerative diseases including Alzheimer's disease (AD) and Parkinson's disease (PD). These diseases are characterized by the progressive degeneration of neurons, resulting in a broad spectrum of clinical manifestations. AD is typified by a progressive decline in cognitive abilities, while PD is marked by motor symptoms associated with the loss of dopamine (DA). : Five different databases, ScienceDirect, Scopus, Wiley, PubMed, and Web of Science (WoS), were reviewed and the studies were screened for inclusion by the following criteria: (i) studies that specifically evaluated the use of , subsp. infantis, or as a therapeutic intervention, either in human or animal models, in the context of neurodegenerative diseases; (ii) the studies were required to address one or more of the pathologies examined in this article, and the pathologies included, but were not limited to, neurodegeneration, Alzheimer's disease, Parkinson's disease, and oxidative stress; (iii) the full text was accessible online; and (iv) the article was written in English. : The data suggest that these probiotics have neuroprotective effects that may delay disease progression. : This study provides updated insights into the use of these strains in neurodegenerative diseases like AD and PD, with the main limitation being the limited number of clinical trials available.
本系统综述聚焦于收集关于单独使用、联合使用或与其他菌株组合使用嗜酸乳杆菌（或婴儿亚种）和双歧杆菌，治疗包括阿尔茨海默病（AD）和帕金森病（PD）在内的神经退行性疾病的最重要研究结果。这些疾病的特征是神经元进行性退化，导致广泛的临床表现。AD的典型特征是认知能力逐渐下降，而PD的特征是与多巴胺（DA）丧失相关的运动症状。检索了五个不同的数据库，即科学Direct、Scopus、Wiley、PubMed和科学网（WoS），并根据以下标准筛选纳入研究：（i）在神经退行性疾病背景下，专门评估嗜酸乳杆菌、婴儿亚种或双歧杆菌在人类或动物模型中作为治疗干预措施使用的研究；（ii）要求研究涉及本文所研究的一种或多种病理情况，这些病理情况包括但不限于神经退行性变、阿尔茨海默病、帕金森病和氧化应激；（iii）全文可在线获取；（iv）文章为英文撰写。数据表明，这些益生菌具有神经保护作用，可能会延缓疾病进展。本研究为这些菌株在AD和PD等神经退行性疾病中的应用提供了最新见解，主要局限性在于可用的临床试验数量有限。
