Herberman R B
Ann Allergy. 1985 May;54(5):376-80.
I believe that the prospects for therapy of cancer by biological response modification are quite good, particularly since this offers an approach to affecting tumor cells which is substantially different from conventional chemotherapy or radiotherapy. But in view of the quite limited success from empirical approaches with immunotherapy or other forms of biological response modification, and the quite unimpressive results that have been seen in patients with advanced disease, I feel that a shift in emphasis to more systematic and well planned studies is needed. It will probably be necessary to develop a detailed understanding of the mechanisms of action of the various BRMs to better understand the immunoregulatory processes affected by these agents, and to develop protocols which are able to produce optimal and sustained alterations in immunologic reactivity. Since a variety of BRMs have shown considerable antitumor effects in animal tumor model systems, particularly against micrometastatic disease which represents a major clinical problem, further research in this area may be expected to lead to significant advances in the therapy of patients with cancer.
我认为通过生物反应修饰来治疗癌症的前景相当不错，特别是因为这提供了一种影响肿瘤细胞的方法，该方法与传统化疗或放疗有很大不同。但是鉴于免疫疗法或其他形式的生物反应修饰的经验性方法取得的成功相当有限，以及在晚期疾病患者中看到的结果相当平淡，我觉得需要将重点转向更系统、规划更完善的研究。可能有必要深入了解各种生物反应调节剂（BRMs）的作用机制，以便更好地理解受这些药物影响的免疫调节过程，并制定能够在免疫反应性方面产生最佳和持续改变的方案。由于多种生物反应调节剂在动物肿瘤模型系统中已显示出相当大的抗肿瘤作用，特别是对代表主要临床问题的微转移疾病，预计该领域的进一步研究可能会在癌症患者的治疗方面取得重大进展。
