Zong Jian-Fa, Hong Zhi-Bo, Hu Zi-Hui, Hou Ru-Yan
National Key Laboratory for Tea Plant Germplasm Innovation and Resource Utilization, Anhui Provincial Key Laboratory of Food Safety Monitoring and Quality Control, Joint Research Center for Food Nutrition and Health of IHM, Anhui Agricultural University, Hefei 230036, China.
Int J Mol Sci. 2025 Jan 28;26(3):1147. doi: 10.3390/ijms26031147.
Two new triterpenoid saponins, namely camsinsaponins A and B (, ), along with two known congeners (, ) were isolated from flowers. Their structures were determined by extensive spectroscopic data. All compounds were assessed for antifungal bioactivity against , , and . Compounds - showed excellent inhibitory effects. Notably, in regard to compounds and , their MIC values against were close to those of the positive control, fluconazole. Furthermore, the inhibitory elements of compounds - on were better than those of fluconazole. The aforementioned findings offer valuable insights for future development of novel therapeutic strategies against drug-resistant infections.
从[花名]中分离出两种新的三萜皂苷，即caminsaponins A和B（[化学式1]，[化学式2]），以及两种已知的同系物（[化学式3]，[化学式4]）。通过广泛的光谱数据确定了它们的结构。评估了所有化合物对[真菌1]、[真菌2]和[真菌3]的抗真菌生物活性。化合物[具体化合物编号1]-[具体化合物编号4]表现出优异的抑制效果。值得注意的是，就化合物[具体化合物编号5]和[具体化合物编号6]而言，它们对[真菌1]的最低抑菌浓度（MIC）值与阳性对照氟康唑相近。此外，化合物[具体化合物编号1]-[具体化合物编号4]对[真菌1]的抑制作用优于氟康唑。上述发现为未来开发针对耐药感染的新型治疗策略提供了有价值的见解。
