Bossola Maurizio, Angioletti Laura, Di Giovanni Marta, Mariani Ilaria, Di Stasio Enrico, Balconi Michela
Servizio Emodialisi, Università Cattolica del Sacro Cuore, 20123 Rome, Italy.
Faculty of Medicine, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, Italy.
J Clin Med. 2025 Jan 29;14(3):883. doi: 10.3390/jcm14030883.
: Over the course of end-stage renal disease, patients undergoing hemodialysis (HD) often face significant psychological distress. Nonetheless, little is known about perceived stress levels and related factors in HD patients. This is a cross-sectional study that explores the prevalence of perceived stress levels and the associated variables in HD patients. : Participants included 223 HD patients recruited in June 2024 in Italy. Perceived stress and depression levels were measured with the Perceived Stress Scale (PSS) and Beck Depression Inventory (BDI-II). We also collected clinical and laboratory variables to evaluate their association with PSS. : PSS score was moderate in 70.8% and high in 11.2% of the patients. The BDI score was significantly higher in patients with moderate or high perceived stress than in those with low perceived stress. The correlation between PSS and BDI scores was statistically highly significant, and in multivariate regression analysis, PSS score was independently associated with BDI, but not with age, sex, and serum creatinine. Patients with moderate or high perceived stress more frequently had a BDI ≥ 17. In women, with respect to men, the frequency of high and moderate perceived stress was higher. PSS does not correlate with some clinical characteristics such as functional disability (ADL and IADL scores), and the number of comorbidities (Charlson comorbidity Index). Also, we found that there was no correlation between PSS and post-dialysis fatigue prevalence/characteristics, nor between PSS and time of recovery after dialysis. : These findings emphasize the critical need for targeted interventions addressing stress management in HD patients, especially with gender-specific approaches.
在终末期肾病病程中，接受血液透析（HD）的患者常面临显著的心理困扰。尽管如此，对于HD患者的感知压力水平及相关因素却知之甚少。这是一项横断面研究，旨在探究HD患者感知压力水平的患病率及相关变量。
参与者包括2024年6月在意大利招募的223名HD患者。使用感知压力量表（PSS）和贝克抑郁量表（BDI-II）测量感知压力和抑郁水平。我们还收集了临床和实验室变量，以评估它们与PSS的关联。
70.8%的患者PSS评分中等，11.2%的患者评分高。感知压力为中度或高度的患者BDI评分显著高于感知压力低的患者。PSS与BDI评分之间的相关性在统计学上高度显著，在多变量回归分析中，PSS评分与BDI独立相关，但与年龄、性别和血清肌酐无关。感知压力为中度或高度的患者更常出现BDI≥17。女性中，与男性相比，高度和中度感知压力的频率更高。PSS与一些临床特征如功能残疾（ADL和IADL评分）以及合并症数量（查尔森合并症指数）无关。此外，我们发现PSS与透析后疲劳患病率/特征之间以及PSS与透析后恢复时间之间均无相关性。
这些发现强调了针对HD患者压力管理进行有针对性干预的迫切需求，尤其是采用针对性别的方法。
