Rochman H, Conniff E S, Kuk-Nagle K T
Ann Clin Lab Sci. 1985 Mar-Apr;15(2):106-8.
Estrogen receptors of primary breast cancer tumors were determined by sedimentation analysis. Positive tumors from pre- and post-menopausal patients were those that contained estrogen receptor content greater than 250 and greater than 750 fmoles per g wet weight tissue, respectively. A positive correlation of patients' age with increasing incidence of estrogen receptor positive tumors was found; test for linear trend significance z = 5.38 (P less than 0.001). One-sixth of those less than 29 years had positive tumors, 27 percent in the age group 40 to 49 years, 46 percent in those 70 to 79 years, and 62 percent in those 80 years or older.
通过沉降分析确定原发性乳腺癌肿瘤的雌激素受体。绝经前和绝经后患者的阳性肿瘤分别是每克湿重组织中雌激素受体含量大于250和大于750飞摩尔的肿瘤。发现患者年龄与雌激素受体阳性肿瘤发病率增加呈正相关；线性趋势显著性检验z = 5.38（P小于0.001）。29岁以下的患者中六分之一有阳性肿瘤，40至49岁年龄组为27%，70至79岁为46%，80岁及以上为62%。
