土曲霉中震颤毒素B’的分离、化学结构、急性毒性及一些理化性质
Isolation, chemical structure, acute toxicity, and some physicochemical properties of territrem B' from Aspergillus terreus.
作者信息
Peng F C, Ling K H, Wang Y, Lee G H
出版信息
Appl Environ Microbiol. 1985 Mar;49(3):721-3. doi: 10.1128/aem.49.3.721-723.1985.
We have isolated a metabolite of territrem, designated territrem B', from the chloroform extract of a rice culture of Aspergillus terreus 23-1 by using the same isolation procedure as that for territrems A, B, and C. The present isolation procedure gave about 10 mg of territrem B' from 4 kg of rice culture per batch. Analysis of the high-resolution mass spectrum showed that the molecular composition of territrem B' is C29H34O10 (found, 542.2167; required, 542.200). Some results of physicochemical and acute tests are presented in this paper. Single-crystal X-ray diffractometry of territrem B' indicated that the three-dimensional structure of territrem B' has not changed significantly from that of territrem B except for the insertion of one oxygen atom into territrem B to make an additional pyron ring in the E ring. The tremorgenic activity of territrem B' is greatly reduced as tested by intraperitoneal injection in mice.
我们采用与从土曲霉23-1的大米培养物中分离出震颤素A、B和C相同的分离方法，从土曲霉23-1的大米培养物的氯仿提取物中分离出一种震颤素的代谢产物，命名为“震颤素B’”。按照目前的分离方法，每批从4千克大米培养物中可得到约10毫克的震颤素B’。高分辨率质谱分析表明，震颤素B’的分子组成为C29H34O10（实测值为542.2167；理论值为542.200）。本文给出了一些物理化学和急性试验的结果。震颤素B’的单晶X射线衍射分析表明，除了在震颤素B的E环中插入一个氧原子形成一个额外的吡喃环外，震颤素B’的三维结构与震颤素B相比没有显著变化。通过对小鼠腹腔注射试验发现，震颤素B’的致震颤活性大大降低。
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