来自土曲霉的震颤毒素C的分离、化学结构、急性毒性及一些理化性质
Isolation, chemical structure, acute toxicity, and some physicochemical properties of territrem C from Aspergillus terreus.
作者信息
Ling K H, Liou H H, Yang C M, Yang C K
出版信息
Appl Environ Microbiol. 1984 Jan;47(1):98-100. doi: 10.1128/aem.47.1.98-100.1984.
Abstract
Territrem C, a new tremorgenic mycotoxin (C28H32O9; molecular weight, 512.20) was isolated from the chloroform extract of rice cultures of Aspergillus terreus 23-1, which also produces territrems A and B. Isolation, acute toxicity, and some physicochemical properties of territrem C are discussed in this paper. The spectral and chemical evidence indicated that the structural difference between territrem C and territrem B (C29H34O9) was in their phenyl moieties: a 4-hydroxy-3,5-dimethoxy phenyl group in territrem C and a 3,4,5-trimethoxy phenyl group in territrem B. It was also demonstrated that territrem B was obtained by methylation of territrem C with dimethyl sulfate.
摘要
震颤毒素C是一种新的致震颤霉菌毒素（C28H32O9；分子量512.20），从土曲霉23 - 1的大米培养物的氯仿提取物中分离得到，该菌株还产生震颤毒素A和B。本文讨论了震颤毒素C的分离、急性毒性及一些物理化学性质。光谱和化学证据表明，震颤毒素C和震颤毒素B（C29H34O9）的结构差异在于它们的苯基部分：震颤毒素C中有一个4 - 羟基 - 3,5 - 二甲氧基苯基，而震颤毒素B中有一个3,4,5 - 三甲氧基苯基。还证明了震颤毒素B是通过用硫酸二甲酯对震颤毒素C进行甲基化得到的。
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