Richmond G W, Abrahams R H, Nemenzo J H, Hine C H
Arch Environ Health. 1985 Jan-Feb;40(1):20-5. doi: 10.1080/00039896.1985.10545884.
A study was made of the effects of ethylene oxide (ETO) on the health of sterilizer workers and other personnel exposed while using ETO for sterilization of disposable medical devices. The only significant findings were obtained by chromosomal analysis of cultured lymphocytes harvested from the workers. There were significant differences in the numbers and types of chromosomal aberrations between the exposed workers and the nonexposed controls. Quadriradial and triradial chromosomal forms, which are rarely found in nonexposed populations, were increased in exposed workers. Increased numbers of sister chromatid exchanges (SCE) were found in the cultured lymphocytes of some, but not all, exposed persons during the 2 yr of study. Thirteen workers were removed from exposure in 1979 because of increased numbers of aberrant cells. Follow-up over 4 yr has not shown a significant improvement, except for a moderate reduction in SCE. Recommendations are given for a surveillance of persons working with or exposed to ethylene oxide.
一项关于环氧乙烷（ETO）对消毒器操作人员及使用ETO对一次性医疗设备进行消毒时其他暴露人员健康影响的研究。唯一显著的发现是通过对从这些工作人员采集的培养淋巴细胞进行染色体分析获得的。暴露工作人员与未暴露对照组之间在染色体畸变的数量和类型上存在显著差异。在未暴露人群中很少发现的四射体和三射体染色体形态在暴露工作人员中有所增加。在为期2年的研究期间，在一些（但并非所有）暴露人员的培养淋巴细胞中发现姐妹染色单体交换（SCE）数量增加。1979年，13名工作人员因异常细胞数量增加而停止暴露。4年多的随访未显示出显著改善，只是SCE有适度减少。针对从事环氧乙烷工作或接触环氧乙烷的人员给出了监测建议。
