Tang Shiwei, Xu Juan, Wan Ping, Jin Shumen, Zhang Ying, Xun Linting, Wang Jinli, Luo Mei, Chen Wenjie, Zuo Zan, Tang Hui, Qi Jialong
School of Medicine, Kunming University of Science and Technology, Kunming, Yunnan, China.
Yunnan Digestive Endoscopy Clinical Medical Center, Department of Gastroenterology, The First People's Hospital of Yunnan Province, Affiliated by Kunming University of Science and Technology, Kunming, Yunnan, China.
Front Immunol. 2025 Jan 29;16:1542157. doi: 10.3389/fimmu.2025.1542157. eCollection 2025.
Dietary behaviors significantly influence tumor progression, with increasing focus on high-salt diets (HSD) in recent years. Traditionally, HSD has been regarded as a major risk factor for multiple health issues, including hypertension, cardiovascular disease, kidney disease, cancer, and osteoporosis. However, recent studies have uncovered a novel aspect of HSD, suggesting that HSD may inhibit tumor growth in specific pathological conditions by modulating the activity of immune cells that infiltrate tumors and enhancing the effectiveness of PD-1 immunotherapy. This review focused on the duel molecular mechanisms of HSD in cancer development, which are based on the tumor microenvironment, the gut microbiota, and the involvement of sodium transporter channels. The objective of this review is to explore whether HSD could be a potential future oncological therapeutic strategy under specific situation.
饮食行为对肿瘤进展有显著影响，近年来人们对高盐饮食（HSD）的关注度不断提高。传统上，高盐饮食一直被视为多种健康问题的主要风险因素，包括高血压、心血管疾病、肾脏疾病、癌症和骨质疏松症。然而，最近的研究发现了高盐饮食的一个新方面，表明高盐饮食可能通过调节浸润肿瘤的免疫细胞活性和增强PD-1免疫疗法的有效性，在特定病理条件下抑制肿瘤生长。本综述聚焦于高盐饮食在癌症发展中的双重分子机制，这些机制基于肿瘤微环境、肠道微生物群以及钠转运通道的参与。本综述的目的是探讨在特定情况下，高盐饮食是否可能成为未来一种潜在的肿瘤治疗策略。
