Barth S I, DeMonaco S M, Conner B J, Wilkinson A R
Department of Small Animal Clinical Sciences, Fetch Specialty and Emergency Veterinary Centers in Brandon, Florida, USA.
Department of Small Animal Clinical Sciences, Long Island University College of Veterinary Medicine, Brookville, New York, USA.
J Small Anim Pract. 2025 Jun;66(6):365-371. doi: 10.1111/jsap.13841. Epub 2025 Feb 13.
Thromboelastography (TEG) using the TEG 6s, a point-of-care viscoelastic assay, was prospectively evaluated in dogs with chronic enteropathy (CE). Additionally, the study determined whether disease activity, assessed using the Canine Chronic Enteropathy Clinical Activity Index (CCECAI), correlated with TEG 6s parameters.
A CCECAI score and TEG using the TEG 6s (Haemonetics®) was performed on 19 dogs with CE. In a separate study, TEG using the TEG 6s was performed on 40 healthy adult dogs, which served as the control group. For statistical analysis, normally distributed data were analysed using the two-sample t-test. Non-Gaussian data were analysed using the Wilcoxon rank sum test. Correlations between TEG 6s parameters and the CCECAI scores were assessed using the Pearson test for data with Gaussian distribution and the Spearman test for data with non-Gaussian distribution.
Dogs with CE had significantly shortened mean clot kinetics, prolonged mean reaction time (R) and increased alpha angle (angle), maximum amplitude (MA) and RapidTEG™ MA compared to healthy dogs. Dogs with CE had a significant median increase in Functional Fibrinogen MA compared to healthy dogs. The CCECAI moderately positively correlated with angle.
With the exception of prolonged R, dogs with CE have several TEG 6s alterations suggestive of hypercoagulability.
前瞻性评估使用TEG 6s即时弹性成像检测技术（一种即时床旁黏弹性检测方法）对患有慢性肠病（CE）的犬进行血栓弹力图（TEG）检测的情况。此外，本研究还确定了使用犬慢性肠病临床活动指数（CCECAI）评估的疾病活动度是否与TEG 6s参数相关。
对19只患有CE的犬进行CCECAI评分及使用TEG 6s（Haemonetics®）进行TEG检测。在另一项研究中，对40只健康成年犬进行使用TEG 6s的TEG检测，作为对照组。对于统计分析，正态分布数据采用两样本t检验进行分析。非高斯分布数据采用Wilcoxon秩和检验进行分析。使用Pearson检验评估高斯分布数据的TEG 6s参数与CCECAI评分之间的相关性，使用Spearman检验评估非高斯分布数据的相关性。
与健康犬相比，患有CE的犬平均凝血动力学显著缩短，平均反应时间（R）延长，α角（angle）、最大振幅（MA）和快速TEG™ MA增加。与健康犬相比，患有CE的犬功能性纤维蛋白原MA的中位数显著增加。CCECAI与角度呈中度正相关。
除R延长外，患有CE的犬存在几种TEG 6s改变，提示高凝状态。
