Public Dental Service, Ljungby Public Dental Clinic, Region Kronoberg, Ljungby, Sweden.
Department of Odontology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
J Dent Res. 2015 Sep;94(9 Suppl):181S-6S. doi: 10.1177/0022034515595950. Epub 2015 Jul 22.
The aim of this study was to investigate the effect of a daily intake of probiotic lactobacilli on the prevalence and counts of oral Candida in frail elderly patients living in nursing homes. The study had a double-blind randomized placebo-controlled design with 2 parallel arms. The study group consisted of 215 older adults (range, 60 to 102 y) who were enrolled after informed consent. After baseline examination and randomization, the subjects were given 1 lozenge containing 2 strains of the probiotic bacterium Lactobacillus reuteri (DSM 17938 and ATCC PTA 5289) or placebo twice daily (morning and evening). The intervention period was 12 wk, and saliva and plaque samples were collected at baseline and follow-up. The primary end point was prevalence of high Candida counts assessed from chairside tests. Secondary end points were levels of dental plaque and gingival inflammation. The groups were balanced at baseline. The attrition rate to follow-up was 19%. There was a statistically significant reduction in the prevalence of high Candida counts in the probiotic group but not in the placebo group, and the difference was statistically significant in both saliva and plaque (P < 0.05). No significant differences between the groups were noted concerning the levels of supragingival plaque or bleeding on probing. Thus, daily use of probiotic lozenges may reduce the prevalence of high oral Candida counts in frail elderly nursing homes residents (ClinicalTrials.gov NCT02391532).
本研究旨在探讨每日摄入益生菌 Lactobacillus 对居住在养老院的体弱老年患者口腔 Candida 流行率和计数的影响。该研究采用双盲随机安慰剂对照设计，有 2 个平行组。研究组由 215 名年龄在 60 至 102 岁之间的老年人（范围）组成，他们在知情同意后被纳入研究。基线检查和随机分组后，受试者每天服用 2 片含有 2 株益生菌 Lactobacillus reuteri（DSM 17938 和 ATCC PTA 5289）的含片或安慰剂，每日 2 次（早晚）。干预期为 12 周，在基线和随访时收集唾液和菌斑样本。主要终点是通过床边试验评估的高 Candida 计数的流行率。次要终点是牙菌斑和牙龈炎症的水平。两组在基线时平衡。随访的失访率为 19%。在益生菌组中，高 Candida 计数的流行率显著降低，但在安慰剂组中没有，并且在唾液和菌斑中差异均具有统计学意义（P < 0.05）。两组之间龈上菌斑或探诊出血水平无显著差异。因此，每日使用益生菌含片可能会降低体弱老年养老院居民口腔高 Candida 计数的流行率（ClinicalTrials.gov NCT02391532）。
