Gay J C, Janco R L, Lukens J N
Cancer. 1985 Jun 1;55(11):2688-90. doi: 10.1002/1097-0142(19850601)55:11<2688::aid-cncr2820551125>3.0.co;2-h.
Systemic metastases from central nervous system germinomas are exceedingly rare, and when they occur lead to fatal outcomes. The authors report the case of a 10-year-old girl who presented with metastatic involvement of the rib and pelvis 2.5 years after surgical resection and radiation therapy for a suprasellar dysgerminoma. After combination chemotherapy, the patient remains disease-free 30 months after relapse. This case provides evidence that chemotherapy can be an effective therapeutic alternative to the use of radiation in the treatment of children with extracranial germinomas.
中枢神经系统生殖细胞瘤发生全身转移极为罕见，一旦发生往往导致致命后果。作者报告了一例10岁女孩的病例，该女孩在接受鞍上生殖细胞瘤手术切除和放射治疗2.5年后出现肋骨和骨盆转移。经过联合化疗，患者在复发后30个月仍无疾病复发。该病例证明，在治疗儿童颅外生殖细胞瘤时，化疗可作为放疗的一种有效替代治疗方法。
