Wu Wenlong, Wang Yue, Li Wenhao, Shen Jiran, Zhang Binbin, Li Pulin, Han Rui, Cao Chao, Wang Ran
Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, China.
Department of Infectious Diseases, the Second People's Hospital of Hefei, Hefei Hospital Affiliated to Anhui Medical University, Hefei 230001, China.
Ecotoxicol Environ Saf. 2025 Feb;291:117901. doi: 10.1016/j.ecoenv.2025.117901. Epub 2025 Feb 16.
Chronic cough, which affects approximately 10 % of the global population, is recognized as a significant health issue, especially among females. Recent research suggests that chronic cough may be an independent disease rather than merely a symptom of other conditions. This study focuses on the potential role of exposure to perfluoroalkyl and polyfluoroalkyl substances (PFAS) in the development of chronic cough, noting that PFAS exposure has been linked to various adverse health outcomes. We aimed to explore the association between PFAS exposure and the risk of chronic cough in the U.S. population, analyzing data from the National Health and Nutrition Examination Survey (NHANES) from 2003 to 2012 and examining potential sex-based differences. Our findings reveal several factors independently associated with an increased incidence of chronic cough, including elevated levels of serum perfluorobutane sulfonic acid (PFBS) and perfluoroheptanoic acid (PFHP). The multi-pollutant models consistently demonstrated a significant positive correlation between PFAS exposure and a higher risk of chronic cough in adult males, with PFBS and PFHP as the primary contributors. However, due to the cross-sectional design of the NHANES study, further research is necessary to elucidate the precise mechanisms by which PFAS contribute to chronic cough.
慢性咳嗽影响着全球约10%的人口，被认为是一个重大的健康问题，尤其是在女性中。最近的研究表明，慢性咳嗽可能是一种独立的疾病，而不仅仅是其他病症的症状。本研究关注接触全氟烷基和多氟烷基物质（PFAS）在慢性咳嗽发展中的潜在作用，指出PFAS暴露与各种不良健康后果有关。我们旨在探讨美国人群中PFAS暴露与慢性咳嗽风险之间的关联，分析2003年至2012年国家健康和营养检查调查（NHANES）的数据，并研究潜在的性别差异。我们的研究结果揭示了几个与慢性咳嗽发病率增加独立相关的因素，包括血清全氟丁烷磺酸（PFBS）和全氟庚酸（PFHP）水平升高。多污染物模型一致表明，PFAS暴露与成年男性患慢性咳嗽的较高风险之间存在显著正相关，PFBS和PFHP是主要促成因素。然而，由于NHANES研究的横断面设计，有必要进行进一步研究以阐明PFAS导致慢性咳嗽的精确机制。
