Price Hillel B, Song Ge, Wang Wan, O'Kane Erin, Lu Kechao, Jelly Evan, Miller David A, Wax Adam
Department of Biomedical Engineering, Duke University, Durham, NC 27708, USA.
Biomed Opt Express. 2025 Jan 30;16(2):748-759. doi: 10.1364/BOE.551625. eCollection 2025 Feb 1.
Low-cost optical coherence tomography (OCT) has shown promise in increasing access to noninvasive retinal imaging at the point of care, especially in low-resource environments. A next-generation low-cost OCT system is presented which improves performance over previous versions by employing balanced detection, improved spectrometer falloff, and an increased A-line rate of 40 kHz. An algorithm is presented for image display that uses a histogram matching procedure to improve contrast-to-noise ratio (CNR). Imaging performance is benchmarked with CNR analysis of retinal OCT images, demonstrating a CNR of 2.01 ± 0.39 (p < 0.0001) for macula images collected during a clinical trial, a significant improvement over previous low-cost OCT systems.
低成本光学相干断层扫描（OCT）已显示出有望在医疗现场增加非侵入性视网膜成像的可及性，尤其是在资源匮乏的环境中。本文介绍了一种下一代低成本OCT系统，该系统通过采用平衡检测、改善光谱仪衰减以及将A线速率提高到40 kHz，在性能上优于先前版本。本文还提出了一种用于图像显示的算法，该算法使用直方图匹配程序来提高对比度噪声比（CNR）。通过对视网膜OCT图像进行CNR分析来衡量成像性能，结果表明，在一项临床试验中收集的黄斑图像的CNR为2.01±0.39（p<0.0001），与先前的低成本OCT系统相比有显著改善。
