Rahmani Parisa, Ebrahimi Maryam, Rohani Pejman, Sohouli Mohammad Hassan, Magalhães Elma Izze da Silva
Pediatric Gastroenterology and Hepatology Research Center, Pediatrics Centre of Excellence, Children's Medical Center Tehran University of Medical Sciences Tehran Iran.
Postgraduate Program in Food, Nutrition and Health, Federal University of Rio Grande Do Sul Porto Alegre Rio Grande do Sul Brazil.
JGH Open. 2025 Feb 17;9(2):e70119. doi: 10.1002/jgh3.70119. eCollection 2025 Feb.
Bowel preparation can directly affect the final outcome of a colonoscopy. However, limited studies have been conducted regarding the effect of probiotics on intestinal preparation. Thus, the present study aims to investigate the effect of probiotics in the bowel preparation regimen of children who are candidates for colonoscopy.
In this double-blind, placebo-controlled, randomized clinical trial, 84 colonoscopy candidate pediatric patients were enrolled. Patients were divided into two equal groups of 42 individuals. One group of patients underwent the bisacodyl, polyethylene glycol regimen 48 h before colonoscopy, as along with a placebo. The other group was administered 10 days before colonoscopy and also received bisacodyl and polyethylene glycol 48 h before the procedure. Then, the bowel preparation of the patients was assessed using the Boston Bowel Preparation Scale (BBPS).
The mean age of patients in the placebo and probiotic groups was 94.1 ± 43.8 and 111.2 ± 48.8 months, respectively ( = 0.10). The preparation of the left colon was not significantly different between the placebo and probiotic groups ( = 0.075). The effect of probiotic on the preparation of the right colon was excellent in 18 patients (42.86%) and good in 17 patients (40.47%). The preparation of the right colon was significantly different between the placebo and probiotic groups ( = 0.007). Based on the results, there was a significant association between the consumption of and placebo in the preparation of the transverse colon ( = 0.015).
Probiotic pretreatment as part of bowel preparation significantly improves visualization of the colonic mucosa during colonoscopy.
肠道准备可直接影响结肠镜检查的最终结果。然而，关于益生菌对肠道准备效果的研究有限。因此，本研究旨在探讨益生菌在结肠镜检查候选儿童肠道准备方案中的作用。
在这项双盲、安慰剂对照、随机临床试验中，纳入了84例结肠镜检查候选儿科患者。患者被平均分为两组，每组42人。一组患者在结肠镜检查前48小时采用比沙可啶、聚乙二醇方案，并服用安慰剂。另一组在结肠镜检查前10天服用益生菌，在检查前48小时也接受比沙可啶和聚乙二醇。然后，使用波士顿肠道准备量表（BBPS）评估患者的肠道准备情况。
安慰剂组和益生菌组患者的平均年龄分别为94.1±43.8个月和111.2±48.8个月（P=0.10）。安慰剂组和益生菌组左半结肠的准备情况无显著差异（P=0.075）。益生菌对右半结肠的准备效果在18例患者中为优（42.86%），17例患者中为良（40.47%）。安慰剂组和益生菌组右半结肠的准备情况有显著差异（P=0.007）。根据结果，在横结肠准备中，益生菌组与安慰剂组之间存在显著关联（P=0.015）。
作为肠道准备一部分的益生菌预处理可显著改善结肠镜检查期间结肠黏膜的可视化。
