Fabricius P J, Gyde S N, Shouler P, Keighley M R, Alexander-Williams J, Allan R N
Gut. 1985 May;26(5):461-5. doi: 10.1136/gut.26.5.461.
The natural history of Crohn's disease in 47 patients, 60 years of age or older at the time of diagnosis has been defined, and their clinical management and long term prognosis reviewed. Distal colonic involvement is common in this group while extensive colonic and diffuse small bowel disease is rare. Distal colonic involvement usually carries a good prognosis except for those few patients who present with perforation which accounts for most of the disease related mortality. The pattern of distal ileal disease is similar to that observed in the younger patients except for the acute nature of symptoms at first presentation, and the low recurrence rates after initial surgical resection.
已明确47例诊断时年龄在60岁及以上的克罗恩病患者的自然病史，并对其临床管理和长期预后进行了回顾。该组患者中结肠远端受累常见，而广泛的结肠和弥漫性小肠疾病罕见。除少数出现穿孔的患者外，结肠远端受累通常预后良好，穿孔是大多数与疾病相关死亡的原因。回肠远端疾病的模式与年轻患者相似，只是首次出现症状时具有急性特点，且初次手术切除后的复发率较低。
