Tu Yangli, Wu Changbing, Chen Liang, Cen Yinzhi, Liu Jie
Guiyang Fourth People's Hospital, Guiyan, Guizhou Province, China.
College of Pharmacy, Guizhou Medical University, Guiyan, Guizhou Province, China.
Medicine (Baltimore). 2024 Dec 27;103(52):e41060. doi: 10.1097/MD.0000000000041060.
As the global population ages, senile severe pneumonia has become a prominent health challenge. Conventional drug treatments have limitations. Meanwhile, 4 types of traditional Chinese medicine injections have shown potential. Thus, it's necessary to use network meta-analysis to comprehensively evaluate their combined effect with conventional drugs on this disease.
China National Knowledge Infrastructure, VIP shop Database, WanFang database, PubMed, and Cochrane Library were included in randomized controlled studies on traditional Chinese medicine injections for the treatment of senile severe pneumonia from the establishment of the library to January 2023. The literature was assessed for risk of bias using the Review Manager 5.3 software. Study outcome indicators were statistically analyzed using Stata 14.0 and Review Manager 5.3 software.
Thirty-three studies were included with a total of 2598 patients. The main outcome indicator was the clinical effective rate. Secondary outcome indicators were white blood cell count, procalcitonin, and C-reactive protein. The results of network meta-analysis showed that clinical efficacy of Reduning injection combined with conventional drug had the better effect. Xiyanping injection combined with conventional drug could better reduce white blood cell and C-reactive protein indicators. Xuebijing injection combined with conventional drug had better ability to reduce procalcitonin.
Reduning injection, Xiyanping injection, Tanreqing injection, and Xuebijing injection combined with conventional drugs in the treatment of senile severe pneumonia can improve the clinical effect.
随着全球人口老龄化，老年重症肺炎已成为一项突出的健康挑战。传统药物治疗存在局限性。同时，4种中药注射剂已显示出潜力。因此，有必要采用网状Meta分析来综合评估它们与传统药物联合治疗该病的效果。
纳入中国知网、维普资讯网、万方数据库、PubMed及Cochrane图书馆中自建库至2023年1月有关中药注射剂治疗老年重症肺炎的随机对照研究。采用Review Manager 5.3软件对文献进行偏倚风险评估。使用Stata 14.0及Review Manager 5.3软件对研究结局指标进行统计分析。
共纳入33项研究，总计2598例患者。主要结局指标为临床有效率。次要结局指标为白细胞计数、降钙素原及C反应蛋白。网状Meta分析结果显示，热毒宁注射液联合传统药物的临床疗效更佳。喜炎平注射液联合传统药物能更好地降低白细胞及C反应蛋白指标。血必净注射液联合传统药物降低降钙素原的能力更佳。
热毒宁注射液、喜炎平注射液、痰热清注射液及血必净注射液联合传统药物治疗老年重症肺炎可提高临床疗效。
