热毒宁注射液联合西药治疗肺炎：一项系统评价与Meta分析方案
Reduning injection combined with western medicine for pneumonia: A protocol for systematic review and meta-analysis.
作者信息
Cao Chenggang, Zhen Zelong, Kuang Shengnan, Xu Tao
机构信息
Chongqing Rongchang District People's Hospital.
Chongqing Fifth People's Hospital, Chongqing, Chongqing Municipality, China.
出版信息
Medicine (Baltimore). 2020 Oct 23;99(43):e22757. doi: 10.1097/MD.0000000000022757.
BACKGROUND
Pneumonia is a common respiratory disease. In severe cases, it can induce cardiovascular disease and even life-threatening. In particular, pneumonia caused by the new coronavirus (SARS-CoV-2) that broke out at the end of 2019 has seriously affected the health of people in all countries. In recent years, it has been treated with the combination of traditional Chinese medicine (TCM) (such as Reduning injection) and Western medicine, and its mortality has decreased significantly. But their efficacy has not been scientifically and systematically assessed. Accordingly, it is essential to provide a systematized review program to estimate the efficacy and safety of Reduning injection combined with Western medicine to treat pneumonia.
METHODS
The following databases are retrieved from start to September 2020: Pubmed, Cochrane Library, EMBASE, Web of Science, Chinese National Knowledge Infrastructure (CNKI), Wanfang database, the Chongqing VIP Chinese Science and Technology Periodical Database (VIP) databases, Chinese Biomedical Literature Database (CBM), and other databases, which are absorbed into clinical RCTs of pneumonia using western medicine alone or plus Reduning injections. The selection of studies, data extraction, and assessment of risk of bias will be performed independently by 2 reviewers. At the same time, Review Manager V.5.3.5 (Rev Man V.5.3.5) was used for bias risk assessment and data synthesis.
RESULTS
The efficacy and safety of Reduning injection combined with western medicine in the treatment of pneumonia were evaluated in terms of overall effective rate, the patient's antipyretic time, antitussive time, rales disappearing time, X-ray recovery time, and the incidence of adverse reactions.
CONCLUSIONS
This study provides reliable evidence-based support for the clinical application of Reduning injection combined with western medicine for pneumonia.
ETHICS AND DISSEMINATION
Ethical approval is not required in this secondary research evidence, and we will publish the results of this study in a journal or relevant conferences.
REGISTRATION NUMBER
DOI 10.17605/OSF.IO/VS75Y.
背景
肺炎是一种常见的呼吸道疾病。严重时，它可诱发心血管疾病甚至危及生命。特别是2019年底爆发的新型冠状病毒（SARS-CoV-2）引起的肺炎，严重影响了各国人民的健康。近年来，采用中药（如热毒宁注射液）与西药联合治疗，其死亡率显著下降。但其疗效尚未得到科学系统的评估。因此，有必要提供一个系统的综述方案，以评估热毒宁注射液联合西药治疗肺炎的疗效和安全性。
方法
检索截至2020年9月的以下数据库：Pubmed、Cochrane图书馆、EMBASE、科学网、中国知网、万方数据库、重庆维普中文科技期刊数据库（维普）、中国生物医学文献数据库（CBM）等数据库，纳入单用西药或加用热毒宁注射液治疗肺炎的临床随机对照试验。研究的选择、数据提取和偏倚风险评估将由2名评审员独立进行。同时，使用Review Manager V.5.3.5（Rev Man V.5.3.5）进行偏倚风险评估和数据合成。
结果
从总有效率、患者退热时间、止咳时间、啰音消失时间、X线恢复时间和不良反应发生率等方面评估热毒宁注射液联合西药治疗肺炎的疗效和安全性。
结论
本研究为热毒宁注射液联合西药治疗肺炎的临床应用提供了可靠的循证支持。
伦理与传播
本二次研究证据无需伦理批准，我们将在期刊或相关会议上发表本研究结果。
注册号
DOI 10.17605/OSF.IO/VS75Y。
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