Yang Kuiliang, Wu Shangcao, Ke Lan, Zhang Han, Wan Shanshan, Lu Mingzhi, Mao Jiewen, Gao Yuelan, Yang Yanning, Xing Yiqiao, Yang Wanju
Aier Eye Hospital of Wuhan University, Wuhan, China.
Eye Center, Renmin Hospital of Wuhan University, Wuhan, China.
Medicine (Baltimore). 2024 Dec 27;103(52):e41019. doi: 10.1097/MD.0000000000041019.
The 2017 TFOS DEWS II report provided an overview of the epidemiology of dry eye disease (DED) and identified several potential risk factors. This study aimed to conduct a meta-analysis on these potential risk factors.
A comprehensive systematic search was conducted in PubMed, Embase, Web of Science, and Cochrane Library databases to include observational studies. Two researchers independently extracted adjusted odds ratios (AORs) and their 95% confidence intervals (CIs), and a random-effects model was used to combine the data. Results were reported using odds ratios (ORs) and their 95% CIs.
The meta-analysis results showed that the risk factors for DED were smoking (OR 1.18, 95% CI 1.07-1.29), alcohol consumption (OR 1.18, 95% CI 1.03-1.35), rosacea or acne (OR 1.96, 95% CI 1.56-2.45), allergic conjunctivitis (OR 4.59, 95% CI 3.38-6.23), refractive surgery (OR 1.78, 95% CI 1.05-3.00), diabetes (OR 1.14, 95% CI 1.06-1.22), thyroid disease (OR 1.57, 95% CI 1.36-1.82), viral infections (OR 1.54, 95% CI 1.33-1.78), anxiety (OR 2.39, 95% CI 1.30-4.39), depression (OR 1.59, 95% CI 1.39-1.82), post-traumatic stress disorder (OR 1.43, 95% CI 1.42-1.45), and stress (OR 1.59, 95% CI 1.24-2.05). However, there was no significant association between Hispanic ethnicity, menopause, past smoking, current smoking, multivitamin use, and DED.
These findings provide valuable insights for further research on the prevention and treatment of dry eye disease.
2017年TFOS DEWS II报告概述了干眼病（DED）的流行病学，并确定了几个潜在风险因素。本研究旨在对这些潜在风险因素进行荟萃分析。
在PubMed、Embase、Web of Science和Cochrane图书馆数据库中进行全面的系统检索，以纳入观察性研究。两名研究人员独立提取调整后的比值比（AORs）及其95%置信区间（CIs），并使用随机效应模型合并数据。结果以比值比（ORs）及其95% CIs报告。
荟萃分析结果显示，DED的风险因素包括吸烟（OR 1.18，95% CI 1.07 - 1.29）、饮酒（OR 1.18，95% CI 1.03 - 1.35）、酒渣鼻或痤疮（OR 1.96，95% CI 1.56 - 2.45）、过敏性结膜炎（OR 4.59，95% CI 3.38 - 6.23）、屈光手术（OR 1.78，95% CI 1.05 - 3.00）、糖尿病（OR 1.14，95% CI 1.06 - 1.22）、甲状腺疾病（OR 1.57，95% CI 1.36 - 1.82）、病毒感染（OR 1.54，95% CI 1.33 - 1.78）、焦虑（OR 2.39，95% CI 1.30 - 4.39）、抑郁（OR 1.59，95% CI 1.39 - 1.82）、创伤后应激障碍（OR 1.43，95% CI 1.42 - 1.45）和压力（OR 1.59，95% CI 1.24 - 2.05）。然而，西班牙裔种族、更年期、既往吸烟、当前吸烟、多种维生素使用与DED之间无显著关联。
这些发现为干眼病的预防和治疗的进一步研究提供了有价值的见解。
