Collins B J, Crothers G, McFarland R J, Love A H
Gut. 1985 May;26(5):495-9. doi: 10.1136/gut.26.5.495.
Intragastric total bile acid concentrations were measured before and after a corn oil test meal in 16 patients with erosive oesophagitis and symptoms of gastro-oesophageal reflux. Sixteen age and sex matched control subjects were also studied. No significant difference was detected between fasting or postprandial gastric bile acid concentrations in patients and in control subjects although a wide range of bile acid concentrations was detected among individuals in both groups. Gastric juice pH was less than 3.5 in seven patients when intragastric bile acid concentrations were greater than 200 mumol/l. These results do not support a role for abnormal duodenogastric reflux in the pathogenesis of erosive oesophagitis. The detection of acid reflux in such patients during intra-oesophageal pH monitoring, however, does not exclude the presence of bile acids which may contribute to the cytotoxic potential of gastric juice.
对16例患有糜烂性食管炎且有胃食管反流症状的患者，在给予玉米油试验餐前后测量其胃内总胆汁酸浓度。还研究了16名年龄和性别匹配的对照受试者。尽管两组个体的胆汁酸浓度范围较广，但患者和对照受试者的空腹或餐后胃胆汁酸浓度均未检测到显著差异。当胃内胆汁酸浓度大于200μmol/L时，7例患者的胃液pH值小于3.5。这些结果不支持十二指肠-胃反流异常在糜烂性食管炎发病机制中的作用。然而，在食管pH监测期间检测到此类患者存在酸反流，并不排除胆汁酸的存在，胆汁酸可能会增加胃液的细胞毒性。
