Ibrahim Hoda Atef Abdelsattar, Sobhi Rodina, Khaled Farouk Nouran, Mohamed AbdelAziz Faten
Lecturer, Pediatric Clinical Nutrition Unit, Department of Pediatrics, Faculty of Medicine, Cairo University, Cairo 12613, Giza, 11562, Egypt.
Department of Pediatrics, Faculty of Medicine, Cairo University, Cairo 12613, Giza, 11562, Egypt.
Pediatr Res. 2025 Feb 19. doi: 10.1038/s41390-025-03913-5.
Overweight and obese children are risky for developing chronic cardiovascular disorders. Heart rate variability is a valuable indicator of the cardiovascular health.
To outline the impact of supplementation of omega-3 on the variability of the heart rate.
A randomized interventional control study has been done on 60 overweight and obese children; 30 children were assigned to the interventional group who received omega-3 with the standard recommendations and 30 children were assigned to the control group who received the standard recommendations only. Resting 10 min Holter ECG was done at the start and after 3 months of omega-3 supplementation in both groups to observe and compare the difference in the heart rate variability. In addition, lipid profiles were investigated and compared.
Difference in measures of the heart rate variability; RMSSD, SDNN, and pNN50 were increased significantly in cases compared to the controls (P value = 0.017, 0.009, and 0.043 respectively). Differences in measures of the lipid profiles differed only in triglycerides which decreased significantly in cases and HDL which increased significantly in the cases (P value = 0.006, 0.005 respectively).
Our results suggested that omega-3 supplementation might improve cardiovascular health in overweight and obese children.
This study discloses the importance of supplementation of omega-3 fatty acids as a cardioprotective dietary supplement. Omega-3 fatty acids can improve heart rate variability in overweight and obese children. Omega-3 fatty acids can also improve the lipid profiles in overweight and obese children.
超重和肥胖儿童患慢性心血管疾病的风险较高。心率变异性是心血管健康的一个重要指标。
概述补充ω-3对心率变异性的影响。
对60名超重和肥胖儿童进行了一项随机干预对照研究；30名儿童被分配到干预组，按照标准建议服用ω-3，30名儿童被分配到对照组，仅接受标准建议。两组在开始时以及服用ω-3 3个月后进行10分钟静息动态心电图检查，以观察和比较心率变异性的差异。此外，还对血脂水平进行了调查和比较。
与对照组相比，干预组心率变异性指标（RMSSD、SDNN和pNN50）显著增加（P值分别为0.017、0.009和0.043）。血脂指标的差异仅体现在甘油三酯上，干预组甘油三酯显著降低，高密度脂蛋白显著升高（P值分别为0.006、0.005）。
我们的结果表明，补充ω-3可能改善超重和肥胖儿童的心血管健康。
本研究揭示了补充ω-3脂肪酸作为一种心脏保护膳食补充剂的重要性。ω-3脂肪酸可以改善超重和肥胖儿童的心率变异性。ω-3脂肪酸还可以改善超重和肥胖儿童的血脂水平。
