Kallistratos G, Levkut M, Evangelou A, Kalfakakou V, Vezyraki P, Donos A
Int J Vitam Nutr Res. 1985;55(1):79-84.
The effect of high doses vitamin B12 on the nucleus-bearing erythrocytes in the peripheral blood of the frog, chicken and trout has been investigated. The i.p. and i.m. injection of 5 mg B12/animal, caused the separation of the nucleus from the cytoplasm of the erythrocytes to various degrees. The most pronounced effect was observed in trouts, where 75% of the erythrocytes lost their cytoplasm. Frog and chicken were less susceptible to the denucleating effect of B12. About 10-15% of the frog and chicken erythrocytes lost their cytoplasm 7-8 weeks after the B12 injection.
研究了高剂量维生素B12对青蛙、鸡和鳟鱼外周血中有核红细胞的影响。腹腔注射和肌肉注射5毫克B12/只动物，会导致红细胞的细胞核与细胞质不同程度地分离。在鳟鱼中观察到最明显的效果，其中75%的红细胞失去了细胞质。青蛙和鸡对B12的去核作用不太敏感。在注射B12后7-8周，约10-15%的青蛙和鸡红细胞失去了细胞质。
