Nugroho Anung Noto, Soetrisno Soetrisno, Mudigdo Ambar, Yarso Kristanto Yuli, Indarto Dono, Wahyudi Akmal Zhahir, Budiono Enrico Ananda, Yasyfin Auliya Yudia
Doctoral Program of Medical Sciences, Faculty of Medicine, Sebelas Maret University, Surakarta 57126, Jawa Tengah, Indonesia.
Obstetrics and Gynecology Department, Dr. Moewardi Hospital/Faculty of Medicine, Sebelas Maret University, Surakarta 57161, Jawa Tengah, Indonesia.
Surg Open Sci. 2025 Jan 25;24:5-15. doi: 10.1016/j.sopen.2025.01.006. eCollection 2025 Mar.
Bile duct injuries (BDI) from surgical procedures pose significant clinical challenges, requiring precise interventions for optimal outcomes. This systematic review explores the utilization of grafts in the repair of bile duct injuries, aiming to gain insights from existing literature. Graft-based techniques show promise in improving postoperative outcomes, but their efficacy varies. A systematic search was conducted across PubMed, Science Direct, and Scopus following the PRISMA 2020 Checklist, focusing on studies published until February 19, 2024. The inclusion criteria involved research using grafts to treat bile duct injuries in pig, swine, or mini-pig models. Out of 2231 studies identified, eleven met the inclusion criteria. These studies evaluated various graft techniques, including autologous tissue with biodegradable stents, decellularized grafts, patches, prosthetic grafts, bacterial cellulose film, and heterogeneous materials. Each method had distinct advantages and limitations, particularly regarding postoperative outcomes and histological findings. This review highlights the need for further research to determine the most effective graft-based strategies for BDI repair and improve patient care.
手术过程中造成的胆管损伤（BDI）带来了重大的临床挑战，需要精确的干预措施以实现最佳治疗效果。本系统综述探讨了移植物在胆管损伤修复中的应用，旨在从现有文献中获取见解。基于移植物的技术在改善术后结果方面显示出前景，但其疗效各不相同。按照PRISMA 2020清单，在PubMed、Science Direct和Scopus数据库中进行了系统检索，重点关注截至2024年2月19日发表的研究。纳入标准包括使用移植物治疗猪、猪或小型猪模型中胆管损伤的研究。在识别出的2231项研究中，有11项符合纳入标准。这些研究评估了各种移植物技术，包括带有可生物降解支架的自体组织、脱细胞移植物、补片、人工合成移植物、细菌纤维素膜和异种材料。每种方法都有独特的优点和局限性，特别是在术后结果和组织学发现方面。本综述强调需要进一步研究，以确定用于BDI修复的最有效的基于移植物的策略，并改善患者护理。
