Kumar Vishal, Ifthekar Syed, Raj Vikash, Varikasuvu Seshadri Reddy, Jain Aakash, Vatkar Arvind, Kandwal Pankaj, Barik Sitanshu
Additional Professor, Orthopedics, PGIMER, Chandigarh, India.
Assistant Professor, Orthopedics, All India Institute of Medical Sciences, Bibinagar, India.
Maedica (Bucur). 2024 Dec;19(4):816-822. doi: 10.26574/maedica.2024.19.4.8162024;.
With numerous studies reporting on the clinical efficacy of ozone therapy, there has been a growing interest in its use for disc herniation in lumbar disc disease. The aim of this meta-analysis is to explore the results of the prospective studies using ozone for the treatment of lumbar disc disease.
Online electronic databases of PubMed, Embase and Scopus were searched using relevant keywords. This review included prospective studies on the treatment of lumbar disc herniation using ozone therapy.
A mean improvement of 4.25 (95% CI 2.93-5.58) in visual analogue scale (VAS) scores was noted. A mean improvement of 20.57 (95% CI 18.47-22.68) in Oswestry disability index (ODI) was noted across the studies on meta-analysis. Meta-regression of the pre-operative and post-operative VAS score did not show any significant association with age at procedure, gender or the level of lumbar disc disease. None of the selected studies reported any minor or major complication.
Ozone treatment in low back pain associated with herniated disc is an effective therapy and can be considered as a standard treatment in cases which failed for conservative treatment. Ozone therapy is a simple method and can be effectively delivered with minimal adverse effects. However, additional meta-analysis with high quality randomised controls can be done to further strengthen the evidence for this mode of treatment.
众多研究报道了臭氧疗法的临床疗效，其在腰椎间盘疾病椎间盘突出症治疗中的应用受到越来越多的关注。本荟萃分析的目的是探讨使用臭氧治疗腰椎间盘疾病的前瞻性研究结果。
使用相关关键词检索PubMed、Embase和Scopus在线电子数据库。本综述纳入了使用臭氧疗法治疗腰椎间盘突出症的前瞻性研究。
视觉模拟量表（VAS）评分平均改善4.25（95%可信区间2.93 - 5.58）。在荟萃分析的各项研究中，Oswestry功能障碍指数（ODI）平均改善20.57（95%可信区间18.47 - 22.68）。术前和术后VAS评分的荟萃回归未显示与手术时年龄、性别或腰椎间盘疾病水平有任何显著关联。所选研究均未报告任何轻微或严重并发症。
臭氧治疗椎间盘突出症相关的腰痛是一种有效的治疗方法，对于保守治疗失败的病例可考虑作为标准治疗。臭氧疗法是一种简单的方法，能有效实施且副作用最小。然而，可以进行更多高质量随机对照的荟萃分析，以进一步加强这种治疗方式的证据。
