Sonnenblick M, Abraham A S
Isr J Med Sci. 1985 Mar;21(3):276-8.
The efficacy and the risk of toxicity of long-term digoxin therapy were assessed in 81 elderly patients. The findings show that the serum digoxin level did not correlate with the clinical state. Only 47% of the patients were on a dosage considered to be effective by serum digoxin analysis, whereas 38% of the patients had levels below the therapeutic range; 51% of the patients had been treated with pediatric or semipediatric doses only. Electrocardiographic evidence of digoxin toxicity was found in 17%. Routine periodic measurement of serum digoxin did not correlate with better management. The optimum dosage of digoxin in the elderly patient who is not in overt renal failure and who is not particularly underweight would seem to be 0.19 mg/day, i.e., one and one-half tablets of 0.25 mg on alternate days.
对81例老年患者评估了长期地高辛治疗的疗效和毒性风险。研究结果表明，血清地高辛水平与临床状态无关。根据血清地高辛分析，只有47%的患者服用的剂量被认为是有效的，而38%的患者水平低于治疗范围；51%的患者仅接受过儿科或半儿科剂量的治疗。17%的患者有地高辛毒性的心电图证据。血清地高辛的常规定期测量与更好的治疗管理无关。对于没有明显肾衰竭且体重不过低的老年患者，地高辛的最佳剂量似乎是0.19毫克/天，即每隔一天服用一片半0.25毫克的药片。
