Wang Meng-Huan, Jin Yi-Jie, He Meng-Fei, Zhou An-Nan, Zhu Mei-Ling, Lin Feng, Li Wen-Wen, Jiang Zhong-Li
Department of Rehabilitation Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, 210029, China.
Department of Rehabilitation Medicine, Sir Run Run Hospital, Nanjing Medical University, Nanjing, Jiangsu, 211100, China.
Heliyon. 2024 Oct 26;10(21):e39841. doi: 10.1016/j.heliyon.2024.e39841. eCollection 2024 Nov 15.
Cognitive impairment is common in hemodialysis patients, possibly due to inadequate cerebral blood flow during hemodialysis. No effective non-pharmacological interventions are available. This study investigates the impact of hemodialysis-induced cerebral hypoxia on cognitive decline in hemodialysis patients and the potential of transcutaneous auricular vagus nerve stimulation (taVNS) as a non-pharmacological intervention. A randomized controlled trial with 36 participants showed that cognitive performance and cerebral oxygenation in the dorsolateral prefrontal cortex (DLPFC) significantly declined in the sham group. In contrast, taVNS improved cognitive function by increasing cerebral oxygenation, with significant correlations to reaction times and MoCA scores. The study suggests that Hemodialysis-induced cerebral hypoxia may contribute to persistent cognitive decline in MHD patients. However, taVNS could be an effective intervention to prevent cognitive impairment in hemodialysis patients by alleviating cerebral hypoxia.
认知障碍在血液透析患者中很常见，可能是由于血液透析期间脑血流量不足所致。目前尚无有效的非药物干预措施。本研究调查了血液透析引起的脑缺氧对血液透析患者认知功能下降的影响，以及经皮耳迷走神经刺激（taVNS）作为一种非药物干预措施的潜力。一项有36名参与者的随机对照试验表明，假手术组的认知表现和背外侧前额叶皮质（DLPFC）的脑氧合显著下降。相比之下，taVNS通过增加脑氧合改善了认知功能，与反应时间和蒙特利尔认知评估量表（MoCA）评分显著相关。该研究表明，血液透析引起的脑缺氧可能导致维持性血液透析（MHD）患者持续的认知功能下降。然而，taVNS可能是一种有效的干预措施，通过缓解脑缺氧来预防血液透析患者的认知障碍。
