He Yuxi, Ni Han, Kuang Wentao, Fu Liuyi, Yi Shanghui, Zha Wenting, Lyu Yuan
Hunan Key Laboratory of Molecular Epidemiology, School of Medicine, Hunan Normal University, Changsha City, Hunan Province, China.
China CDC Wkly. 2025 Feb 7;7(6):225-229. doi: 10.46234/ccdcw2025.035.
Cervical cancer is a common malignancy in women, with persistent human papillomavirus (HPV) infection as its primary cause. Understanding the progression from HPV infection to cervical cancer is crucial. Mathematical models play a key role in converting clinical trial data into long-term health forecasts, helping decision-makers tackle challenges posed by limited data and uncertain outcomes. This paper reviews transmission dynamics models and advancements in simulating HPV transmission leading to cervical cancer. It evaluates preventive and control measures, focusing on the impact of HPV vaccination across different vaccine types, doses, age groups, and both genders. These model-based assessments aim to provide insights for developing effective strategies to prevent and control HPV-related cervical cancer.
宫颈癌是女性常见的恶性肿瘤,主要由持续性人乳头瘤病毒(HPV)感染引起。了解从HPV感染到宫颈癌的进展至关重要。数学模型在将临床试验数据转化为长期健康预测方面发挥着关键作用,有助于决策者应对数据有限和结果不确定所带来的挑战。本文综述了传播动力学模型以及在模拟导致宫颈癌的HPV传播方面的进展。它评估了预防和控制措施,重点关注不同疫苗类型、剂量、年龄组以及男女两性中HPV疫苗接种的影响。这些基于模型的评估旨在为制定预防和控制HPV相关宫颈癌的有效策略提供见解。
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