Handelsman D J, Staraj S
J Androl. 1985 May-Jun;6(3):144-51. doi: 10.1002/j.1939-4640.1985.tb00830.x.
Paired testicular volumes and weights, as well as age, height, and weight, were recorded from a series of 1056 consecutive necropsies on adult males ranging in age from 18 to 96 years. These data were analyzed to examine the effects of age, nutritional state (standardized body weight), and illness on testicular size. Testicular volume and weight were related by a constant density of 1.038 g/ml, regardless of testicular size, age or illness. Mean testicular volume was correlated with height (r = 0.470), weight (r = 0.504), body surface area (r = 0.549) and standardized body weight (r = 0.152). Advancing age, malnutrition, alcoholism, malignancy, and a chronic, terminal illness were each individual risk factors for reduced testicular size, whereas diabetes, narcotic or other drug usage, and pelvic injury were not associated with reduced testicular volume. Since advancing age, reduced standardized body weight, and some disease states were all associated with diminution of testicular size, the interaction of age, malnutrition, and illness on testicular size were examined by statistical modeling, using multivariate logistic regression and covariance analysis. The associations of alcoholism, malignancy, and chronic, terminal illness with decreased testicular volume were independent of aging or nutritional state. The effects of chronic, terminal illness were mostly explained by the concurrent effects of reductions in standardized body weight (malnutrition). After exclusion of men with diseases shown to be associated with decreased testicular size, he specific effects of age alone demonstrated a reduction in testicular volume only in the 8th decade of life.(ABSTRACT TRUNCATED AT 250 WORDS)
对1056例年龄在18岁至96岁之间的成年男性连续进行尸检，记录其双侧睾丸体积、重量以及年龄、身高和体重。分析这些数据，以研究年龄、营养状况（标准化体重）和疾病对睾丸大小的影响。无论睾丸大小、年龄或疾病如何，睾丸体积与重量的密度恒定为1.038 g/ml。平均睾丸体积与身高（r = 0.470）、体重（r = 0.504）、体表面积（r = 0.549）和标准化体重（r = 0.152）相关。年龄增长、营养不良、酗酒、恶性肿瘤和慢性终末期疾病均为睾丸体积减小的独立危险因素，而糖尿病、使用麻醉剂或其他药物以及盆腔损伤与睾丸体积减小无关。由于年龄增长、标准化体重降低和某些疾病状态均与睾丸体积减小有关，因此通过多因素逻辑回归和协方差分析等统计模型，研究年龄、营养不良和疾病对睾丸大小的相互作用。酗酒、恶性肿瘤和慢性终末期疾病与睾丸体积减小之间的关联独立于年龄或营养状况。慢性终末期疾病的影响大多可由标准化体重降低（营养不良）的同时作用来解释。排除与睾丸体积减小相关疾病的男性后，仅年龄的特定影响显示，仅在80岁时睾丸体积才会减小。（摘要截断于250字）
