da Motta Thiago Peixoto, da Mota Débora Guedes, Bitencourt Fernando Valentim, Jardim Patrick Felix, Abreu Lucas Guimarães, Zina Lívia Guimarães, de Abreu Mauro Henrique Nogueira Guimarães, Vargas-Ferreira Fabiana
Department of Community and Preventive Dentistry, Faculty of Dentistry, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
Department of Dentistry and Oral Health (Periodontology), Aarhus University, Aarhus, Denmark.
J Autism Dev Disord. 2025 Feb 20. doi: 10.1007/s10803-025-06754-7.
This systematic review and meta-analysis aimed to assess and compare the prevalence of dental caries in children and adolescents with and without ASD and identify associated factors. Following the PRISMA guidelines, a comprehensive literature search was conducted across multiple databases, yielding 2,103 studies, from which 25 met inclusion criteria. The primary outcome measure was caries prevalence, analyzed through clinical assessments. Risk of bias was evaluated using an adapted Newcastle-Ottawa Scale. Statistical analysis was performed with Review Manager, using random-effects models to account for heterogeneity, which was assessed with I. Meta-analyses revealed no significant differences between groups for most caries indicators, such as DMFT and dmft indices. However, the mean Caries Per Surface (DMFS) index was significantly higher in ASD patients, suggesting greater caries severity. Our study found a significant difference in dental caries severity between children and adolescents with Autism Spectrum Disorder (ASD) and those without ASD, through the DMFS index.
本系统评价和荟萃分析旨在评估和比较患有和未患有自闭症谱系障碍（ASD）的儿童和青少年的龋齿患病率，并确定相关因素。按照PRISMA指南，在多个数据库中进行了全面的文献检索，共获得2103项研究，其中25项符合纳入标准。主要结局指标为通过临床评估分析的龋齿患病率。使用改编的纽卡斯尔-渥太华量表评估偏倚风险。使用Review Manager进行统计分析，采用随机效应模型来处理异质性，并通过I²进行评估。荟萃分析显示，在大多数龋齿指标（如DMFT和dmft指数）上，两组之间没有显著差异。然而，ASD患者的平均每表面龋损（DMFS）指数显著更高，表明龋齿严重程度更高。我们的研究通过DMFS指数发现，患有自闭症谱系障碍（ASD）的儿童和青少年与未患有ASD的儿童和青少年在龋齿严重程度上存在显著差异。
