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用于组织工程的3D打印壳聚糖基支架的生物学评价

"Biological evaluation of 3D-Printed chitosan-based scaffolds for tissue engineering".

作者信息

Behrooznia Zahra, Nourmohammadi Jhamak, Mohammadi Zahra, Shabani Fatemeh, Mashhadi Rahele

机构信息

College of Interdisciplinary Science and Technology, University of Tehran, Tehran, Iran.

College of Interdisciplinary Science and Technology, University of Tehran, Tehran, Iran.

出版信息

Carbohydr Res. 2025 May;551:109416. doi: 10.1016/j.carres.2025.109416. Epub 2025 Feb 6.

Abstract

Chitosan is a natural polysaccharide with excellent biocompatibility, biodegradability, and antibacterial capabilities, making it a good candidate for tissue engineering. 3D printing has revolutionized biomaterial fabrication owing to its precision, customization, and ability to create complex structures. This article aims to provide an overview of the current advances in 3D printing techniques for fabricating scaffolds based on chitosan and its derivatives. It also describes various printing methods, including extrusion bioprinting technique, inkjet bioprinting, stereolithography, digital light processing, and indirect 3D printing for controlling porosity, mechanical strength, and biological characteristics of chitosan scaffolds for a variety of tissues, like bone, vascular, cardiac, cartilage, and skin. This review also examines the biological properties of 3D-printed chitosan scaffolds. The advancements in biological performance and 3D printing technology indicate a promising future for developing flexible, customized scaffolds consisting of chitosan.

摘要

壳聚糖是一种天然多糖,具有优异的生物相容性、生物降解性和抗菌能力,使其成为组织工程的良好候选材料。3D打印因其精确性、可定制性以及创建复杂结构的能力,彻底改变了生物材料的制造方式。本文旨在概述基于壳聚糖及其衍生物制造支架的3D打印技术的当前进展。它还描述了各种打印方法,包括挤出式生物打印技术、喷墨生物打印、立体光刻、数字光处理以及间接3D打印,用于控制壳聚糖支架对多种组织(如骨、血管、心脏、软骨和皮肤)的孔隙率、机械强度和生物学特性。本综述还研究了3D打印壳聚糖支架的生物学特性。生物学性能和3D打印技术的进步表明,开发由壳聚糖组成的灵活、定制化支架具有广阔的前景。

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