Seraj Hadeel, Alshalan Hanan A, Alemam Reham, Omair Mohammed A
Vitreoretinal Division, King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia.
Rheumatology Unit, Department of Medicine, King Fahad Specialist Hospital, Tabuk, Saudi Arabia.
J Ophthalmic Inflamm Infect. 2025 Feb 20;15(1):10. doi: 10.1186/s12348-025-00454-0.
Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitides (AAV) are a heterogeneous group of rare, autoimmune conditions characterized by widespread, multisystemic inflammation of small to medium-sized blood vessels. We present a case report of a 46-year-old male with a history of prior ischemic strokes and recurrent bilateral non-granulomatous panuveitis associated with a strongly positive cytoplasmic anti-neutrophil cytoplasmic antibody (c-ANCA) titer. Initial treatment with steroids, methotrexate, and rituximab were ineffective, but the condition responded moderately to cyclophosphamide. This case underscores the importance of considering AAV in patients with unexplained ocular inflammation and highlights the role of c-ANCA testing in diagnosing and managing such cases, even in the absence of classic systemic symptoms.
抗中性粒细胞胞浆抗体（ANCA）相关血管炎（AAV）是一组罕见的异质性自身免疫性疾病，其特征是中小血管广泛的多系统炎症。我们报告一例46岁男性病例，该患者有既往缺血性中风病史，复发性双侧非肉芽肿性全葡萄膜炎，其胞浆抗中性粒细胞胞浆抗体（c-ANCA）滴度呈强阳性。最初使用类固醇、甲氨蝶呤和利妥昔单抗治疗无效，但病情对环磷酰胺有中度反应。该病例强调了在不明原因眼部炎症患者中考虑AAV的重要性，并突出了c-ANCA检测在诊断和管理此类病例中的作用，即使在没有典型全身症状的情况下也是如此。
