Pastre Martin, Raffard Stéphane, Mallet Luc, Lopez-Castroman Jorge
Department of Psychiatry, CHU Nimes, Nimes, France.
Institut de Génomique Fonctionnelle, University of Montpellier, CNRS-INSERM, Montpellier, France.
Curr Psychiatry Rep. 2025 Apr;27(4):187-198. doi: 10.1007/s11920-025-01589-6. Epub 2025 Feb 21.
We aimed to investigate the recent understanding of the frequent coexistence of obsessive-compulsive disorder (OCD) and major depression (MDD), exploring both clinical and mechanistic perspectives. Our focus was on deriving conclusions with therapeutic implications.
While biological factors contribute to the development of OCD-MDD, the comorbidity seems to be primarily induced by the convergence of symptoms that complicate the course of OCD. Tailored cognitive-behavioral therapy programs, specifically addressing MDD, alongside SSRI medication, may prove beneficial for patients experiencing moderate to severe forms of this comorbidity. The review underscores the significance of comorbidity from both diagnostic and therapeutic perspectives. However, existing research has yet to offer a clear understanding of the underlying mechanisms. Further research in the field, notably coming from network studies, could enrich our practice by helping to target specific dimensions that underly OCD-MDD comorbidity.
我们旨在研究近期对强迫症（OCD）和重度抑郁症（MDD）经常共存的理解，从临床和机制两个角度进行探讨。我们的重点是得出具有治疗意义的结论。
虽然生物学因素促成了OCD-MDD的发展，但这种共病似乎主要是由使OCD病程复杂化的症状趋同所诱发的。针对MDD的量身定制的认知行为治疗方案，与SSRI药物治疗一起，可能对患有中度至重度这种共病的患者有益。该综述强调了从诊断和治疗角度来看共病的重要性。然而，现有研究尚未对潜在机制提供清晰的理解。该领域的进一步研究，特别是来自网络研究的成果，可能通过帮助针对构成OCD-MDD共病基础的特定维度来丰富我们的实践。
