Persson Anna, Finn Daniel Wallhed, Broberg Alice, Westerberg Amanda, Magnusson Åsa, Molander Olof
Department of Clinical Neuroscience, Center for Psychiatry Research, Karolinska Institutet, Stockholm, Sweden.
The Stockholm Center for Dependency Disorders, Region Stockholm, Stockholm, Sweden.
Front Psychiatry. 2025 Feb 6;16:1473988. doi: 10.3389/fpsyt.2025.1473988. eCollection 2025.
Major depression and alcohol use disorder affect millions of individuals worldwide and cause significant disability. They often occur together, and their co-occurrence is associated with more negative outcomes than each disorder on its own. Yet, there is a lack of knowledge on how to best treat co-occurring depression and alcohol use disorder. A pilot study was conducted to investigate the feasibility, credibility, patient satisfaction, preliminary effect, and potential negative effects of an integrated treatment for depression and alcohol use disorder, which has shown promising results in an earlier pilot trial.
The study was conducted at an outpatient unit in Stockholm, Sweden. Women (n=7) with current depression and alcohol use disorder were offered integrated group treatment that included evidence-based treatment for depression and alcohol use disorder. Criteria for feasibility were based on an earlier study, treatment credibility was measured using the Credibility/Expectancy Questionnaire and patient satisfaction with the Client Satisfaction Questionnaire.
Feasibility, credibility, and patient satisfaction were high. Depression symptom severity and alcohol consumption decreased from baseline to follow up. Negative effects were reported in terms of increased adverse emotional experiences.
The investigated integrated treatment for co-occurring depression and alcohol use disorder continues to show promise. Randomized clinical trials are needed to evaluate its effectiveness.
重度抑郁症和酒精使用障碍影响着全球数百万人,并导致严重的残疾。它们常常同时出现,而且与单独出现每种疾病相比,二者共病会带来更多负面后果。然而,对于如何最佳治疗共病的抑郁症和酒精使用障碍,人们还缺乏了解。此前的一项初步试验已显示出有前景的结果,在此基础上,开展了一项初步研究,以调查针对抑郁症和酒精使用障碍的综合治疗的可行性、可信度、患者满意度、初步疗效及潜在负面影响。
该研究在瑞典斯德哥尔摩的一个门诊部门进行。为患有当前抑郁症和酒精使用障碍的女性(n = 7)提供综合团体治疗,其中包括针对抑郁症和酒精使用障碍的循证治疗。可行性标准基于一项早期研究,使用可信度/预期问卷来衡量治疗可信度,并通过客户满意度问卷来评估患者满意度。
可行性、可信度和患者满意度都很高。从基线到随访,抑郁症状严重程度和酒精消费量均有所下降。报告的负面影响是不良情绪体验增加。
所研究的针对共病的抑郁症和酒精使用障碍的综合治疗继续显示出前景。需要进行随机临床试验来评估其有效性。