Prévost Jérémie, Tailor Nikesh, Leung Anders, Warner Bryce, Safronetz David
Emerg Infect Dis. 2025 Feb;31(2):385-388. doi: 10.3201/eid3102.241532.
We inoculated clinical materials into deer mice to attempt isolation of Sin Nombre virus. We did not observe productive infection in the natural rodent reservoir. Genomic comparisons between rodent reservoirs and human disease may provide insight into hantavirus evolution and genetic determinants, but reverse zoonosis of Sin Nombre virus appears unlikely.
我们将临床材料接种到鹿鼠体内,试图分离出辛诺柏病毒。我们在天然啮齿动物宿主中未观察到有 productive infection。啮齿动物宿主与人类疾病之间的基因组比较可能有助于深入了解汉坦病毒的进化和遗传决定因素,但辛诺柏病毒的反向人畜共患病似乎不太可能。
这里“productive infection”不太明确准确意思,可结合更专业知识进一步准确理解,直译为“生产性感染”不太符合语境,可能是“有效感染”之类的意思。