Guo Zhen, Guo Xia, Xu Hanchi, Chu Haoxuan, Tian Yulin, Wang Shipeng, Wang Yushi
Department of Cardiovascular Medicine, The First Hospital of Jilin University, Changchun, 130021, China.
Lipids Health Dis. 2025 Feb 21;24(1):64. doi: 10.1186/s12944-025-02492-y.
Insulin resistance (IR) reduces insulin efficacy and heightens the danger of cardiovascular diseases including hypertension. The Metabolic Score for Insulin Resistance (METS-IR), which is based on triglyceride (TG) and high-density lipoprotein cholesterol (HDL-C), body mass index (BMI), and fasting glucose levels, provides a simpler way to assess IR. As the hypertension's prevalence increases, particularly in those with metabolic disorders, exploring the relationship between hypertension and METS-IR has become crucial.
16,310 individuals from the 2007-2018 National Health and Nutrition Examination Survey dataset was included. Hypertension was defined by asking participants about their medical history and blood pressure measurements. METS-IR was calculated as follows: ln([ HDL-C (mg/dL)] × [2 × fasting glucose (mg/dL)] + TG (mg/dL) × BMI (kg/m)). The study adjusted for covariates like sex; age; race; poverty-income ratio; marital status; educational background; total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and serum creatinine levels; smoking; stroke; alcohol consumption; diabetes; and coronary heart disease (CHD). This study was conducted using a multi-factor regression model.
This research demonstrated a significant positive relationship between hypertension and METS-IR. Each 1-unit rise in METS-IR corresponds to a 3% higher chance of hypertension (odds ratio [OR], 1.03; 95% confidence interval [CI], 1.03-1.04). In model 3, METS-IR exhibited a notable correlation with hypertension (OR, 3.31; 95% CI, 2.64-4.14; P < 0.001). A threshold effect analysis demonstrated a nonlinear association. Finally, subgroup analyses supported the stability of the relationship between METS-IR and factors such as sex, race, alcohol consumption, CHD, smoking, and stroke (P > 0.05).
METS-IR showed a strong relationship with hypertension and may be an important marker for evaluating metabolic health and the early hypertension danger.
胰岛素抵抗（IR）会降低胰岛素疗效，并增加包括高血压在内的心血管疾病风险。基于甘油三酯（TG）、高密度脂蛋白胆固醇（HDL-C）、体重指数（BMI）和空腹血糖水平的胰岛素抵抗代谢评分（METS-IR）提供了一种更简便的胰岛素抵抗评估方法。随着高血压患病率的上升，尤其是在患有代谢紊乱的人群中，探究高血压与METS-IR之间的关系变得至关重要。
纳入了2007 - 2018年国家健康与营养检查调查数据集的16310名个体。通过询问参与者的病史和测量血压来定义高血压。METS-IR的计算方法如下：ln（[HDL-C（mg/dL）]×[2×空腹血糖（mg/dL）] + TG（mg/dL）×BMI（kg/m））。该研究对性别、年龄、种族、贫困收入比、婚姻状况、教育背景、总胆固醇（TC）、低密度脂蛋白胆固醇（LDL-C）和血清肌酐水平、吸烟、中风、饮酒、糖尿病和冠心病（CHD）等协变量进行了校正。本研究采用多因素回归模型进行。
本研究表明高血压与METS-IR之间存在显著正相关。METS-IR每升高1个单位，高血压发生几率增加3%（优势比[OR]，1.03；95%置信区间[CI]，1.03 - 1.04）。在模型3中，METS-IR与高血压表现出显著相关性（OR，3.31；95%CI，2.64 - 4.14；P < 0.001）。阈值效应分析显示存在非线性关联。最后，亚组分析支持了METS-IR与性别、种族、饮酒、冠心病、吸烟和中风等因素之间关系的稳定性（P > 0.05）。
METS-IR与高血压关系密切，可能是评估代谢健康和早期高血压风险的重要标志物。
