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用于长期精确指尖脉搏监测的抗运动伪像离子电子传感器。

Anti-Motion Artifacts Iontronic Sensor for Long-Term Accurate Fingertip Pulse Monitoring.

作者信息

You Jia, Lu Mingyang, Dazhen Lamu, Gao Mengjie, Zhang Ruiyan, Li Wendong, Lei Fan, Ren Wei, Li Guangxian, Yang Junlong

机构信息

College of Polymer Science and Engineering, National Key Laboratory of Advanced Polymer Materials, Sichuan University, Chengdu, Sichuan, 610065, China.

Key Laboratory of Photovoltaic Materials, School of Materials and New Energy, Ningxia University, Yinchuan, Ningxia, 750021, China.

出版信息

Adv Sci (Weinh). 2025 Apr;12(15):e2414425. doi: 10.1002/advs.202414425. Epub 2025 Feb 22.

DOI:10.1002/advs.202414425
PMID:39985252
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12005763/
Abstract

Flexible pressure sensors have gained attention for their comfort, portability, and potential in long-term pulse monitoring and early cardiovascular disease diagnosis. However, stretching stress during daily activities affects sensor accuracy, causing motion artifacts (MAs) that hinder precise pulse signal detection. To address this challenge, the anti-motion artifact iontronic pressure sensor (S-smooth sensor), featuring a soft-hard stretchable interface with energy dissipation properties is developed. By regulating the local modulus of the encapsulation layer, this structure dissipates stretching stress, achieving an MAs suppression rate of up to 90%, significantly improving pulse signal accuracy and reliability. Additionally, the sensor incorporates a dielectric layer and double electrode layer (EDL) sensing interface, with a low-friction design that ensures high sensitivity (92.76 kPa-¹) and stability, maintaining performance over millions of cycles. The sensor accurately captures heart rate (HR) and pulse peak time differences (Δt) under various finger-bending conditions. When integrated into a portable wireless pulse monitoring system, it shows a heart rate loss rate of only 2.9% during intense physical activity. This approach avoids complex chemical processes and material restrictions, offering a novel solution for motion artifact suppression in sensors, with significant potential for real-time health monitoring and assisted diagnosis.

摘要

柔性压力传感器因其舒适性、便携性以及在长期脉搏监测和早期心血管疾病诊断方面的潜力而受到关注。然而,日常活动中的拉伸应力会影响传感器的准确性,导致运动伪影(MAs),从而阻碍精确的脉搏信号检测。为应对这一挑战,开发了具有抗运动伪影的离子电子压力传感器(S-smooth传感器),其具有软硬可拉伸界面并具备能量耗散特性。通过调节封装层的局部模量,这种结构可耗散拉伸应力,实现高达90%的运动伪影抑制率,显著提高脉搏信号的准确性和可靠性。此外,该传感器集成了介电层和双电极层(EDL)传感界面,采用低摩擦设计,确保了高灵敏度(92.76 kPa⁻¹)和稳定性,在数百万次循环中保持性能。该传感器能在各种手指弯曲条件下准确捕捉心率(HR)和脉搏峰值时间差(Δt)。当集成到便携式无线脉搏监测系统中时,在剧烈体育活动期间其心率丢失率仅为2.9%。这种方法避免了复杂的化学过程和材料限制,为传感器中的运动伪影抑制提供了一种新颖的解决方案,在实时健康监测和辅助诊断方面具有巨大潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3a4d/12005763/84f2cfd5169f/ADVS-12-2414425-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3a4d/12005763/10cbf77a5ecb/ADVS-12-2414425-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3a4d/12005763/ea9b0e1084be/ADVS-12-2414425-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3a4d/12005763/ba1f234d9415/ADVS-12-2414425-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3a4d/12005763/f70d1e8ea175/ADVS-12-2414425-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3a4d/12005763/e5fa56163ec2/ADVS-12-2414425-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3a4d/12005763/84f2cfd5169f/ADVS-12-2414425-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3a4d/12005763/10cbf77a5ecb/ADVS-12-2414425-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3a4d/12005763/ea9b0e1084be/ADVS-12-2414425-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3a4d/12005763/ba1f234d9415/ADVS-12-2414425-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3a4d/12005763/f70d1e8ea175/ADVS-12-2414425-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3a4d/12005763/e5fa56163ec2/ADVS-12-2414425-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3a4d/12005763/84f2cfd5169f/ADVS-12-2414425-g004.jpg

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