Key Laboratory of Organic Optoelectronics and Molecular Engineering of the Ministry of Education, Department of Chemistry, Tsinghua University, Beijing 100084, PR China.
Department of Cardiovascular Disease, Peking University First Hospital, Beijing 100084, PR China.
Sci Adv. 2023 Aug 11;9(32):eadh0615. doi: 10.1126/sciadv.adh0615.
Continuous and reliable monitoring of blood pressure and cardiac function is of great importance for diagnosing and preventing cardiovascular diseases. However, existing cardiovascular monitoring approaches are bulky and costly, limiting their wide applications for early diagnosis. Here, we developed an intelligent blood pressure and cardiac function monitoring system based on a conformal and flexible strain sensor array and deep learning neural networks. The sensor has a variety of advantages, including high sensitivity, high linearity, fast response and recovery, and high isotropy. Experiments and simulation synergistically verified that the sensor array can acquire high-precise and feature-rich pulse waves from the wrist without precise positioning. By combining high-quality pulse waves with a well-trained deep learning model, we can monitor blood pressure and cardiac function parameters. As a proof of concept, we further constructed an intelligent wearable system for real-time and long-term monitoring of blood pressure and cardiac function, which may contribute to personalized health management, precise and early diagnosis, and remote treatment.
连续、可靠的血压和心功能监测对于心血管疾病的诊断和预防具有重要意义。然而,现有的心血管监测方法体积大、成本高,限制了其在早期诊断中的广泛应用。在这里,我们开发了一种基于贴合式、柔性应变传感器阵列和深度学习神经网络的智能血压和心功能监测系统。该传感器具有灵敏度高、线性度好、响应和恢复快、各向同性高等多种优点。实验和模拟协同验证了该传感器阵列无需精确定位即可从手腕处获取高精度、特征丰富的脉搏波。通过结合高质量的脉搏波和经过良好训练的深度学习模型,我们可以监测血压和心功能参数。作为概念验证,我们进一步构建了一个智能可穿戴系统,用于实时和长期监测血压和心功能,这可能有助于个性化健康管理、精确和早期诊断以及远程治疗。